弗林蛋白酶、转移抑制基因23和血管内皮生长因子在老年眼睑基底细胞癌中的表达及意义

发布时间：2018-07-14 08:57

【摘要】：目的检测老年眼睑基底细胞癌中弗林蛋白酶(Furin)、转移抑制基因(nm)23和血管内皮生长因子(VEGF)表达特点及临床意义。方法收集79例老年眼睑基底细胞癌术后组织蜡块及临床资料为观察组,老年基底细胞乳头状瘤术后组织蜡块56例为对照组,切缘为正常皮肤组织的56例为正常对照组,应用免疫组化方法检测3组Furin、nm23和VEGF表达。结果 Furin、nm23和VEGF在3组中表达阳性率差别显著(P均0.01),观察组中Furin、nm23和VEGF表达与肿瘤最大径、脉管浸润和TNM分期密切相关(P均0.05)。观察组中Furin和VEGF表达呈正相关(r=0.04,P=0.043),Furin和nm23表达呈负相关(r=-0.49,P=0.034 8)。结论老年眼睑基底细胞癌术后组织中Furin、nm23和VEGF异常表达,三者在肿瘤癌变及肿瘤进展过程中可能起促进作用。Furin可能通过促进VEGF表达对肿瘤血管生成有一定的调节作用。
[Abstract]:Objective to detect the expression of Furin, metastasis suppressor gene (nm) 23 and vascular endothelial growth factor (VEGF) in eyelid basal cell carcinoma (BCC) and its clinical significance. Methods Seventy-nine cases of eyelid basal cell carcinoma were collected as observation group, 56 cases as control group, 56 cases as normal skin tissue, 56 cases as control group. The expression of Furinnm23 and VEGF was detected by immunohistochemical method. Results the positive rates of Furinnm23 and VEGF in the three groups were significantly different (P0.01). The expression of Furinnm23 and VEGF in the observation group was closely related to the tumor maximum diameter, vascular invasion and TNM staging (all P 0.05). There was a positive correlation between Furin and nm23 expression in the observation group (P 0.043). There was a negative correlation between Furin expression and nm23 expression in the observation group. Conclusion the abnormal expression of Furinnm23 and VEGF may play an important role in carcinogenesis and tumor progression in the elderly patients with BCC. Furin may play a role in regulating tumor angiogenesis by promoting the expression of VEGF.
【作者单位】：复旦大学附属中山医院青浦分院眼科;
【分类号】：R739.7

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