细菌生物膜对置换钛质听骨赝复物听力恢复的影响

发布时间：2018-07-18 09:37

【摘要】：目的探讨生物膜不同成长时期对部分钛质听骨赝复物结构动力行为的影响,为临床治疗分泌性中耳炎等疾病提供理论依据。方法基于人体正常右耳的CT扫描图像,结合自编程序,重建人耳三维有限元模型,对其进行声音传导动力分析,并与实验数据对比。采用频率响应方法对耳结构模型进行计算,同时分析不同生长时期的细菌生物膜生长在人工钛质听骨上对声音传导的影响。结果模拟得到鼓膜凸和镫骨底板振幅与实验数据吻合,验证了模型的正确性。生物膜的存在会使患者听力在低频段有0~1.6 dB的损伤;生物膜沿部分听骨赝复物径向生长会使患者听力在中高频阶段有0~12 dB的损伤,尤其是在8 kHz时,听力损伤高达11.2 dB。结论细菌生物膜对患者听力有影响,在低频段会使患者听力损失,在高频段听力有增加。细菌生物膜在人工听骨上的径向生长会降低听力,影响人工假体对听力恢复正常的工效。
[Abstract]:Objective to investigate the effect of biofilm on the dynamic behavior of titanium ossicular prosthesis in different growing stages, and to provide a theoretical basis for clinical treatment of secretory otitis media. Methods the 3D finite element model of human ear was reconstructed based on CT scan images of human normal right ear, and the acoustic conduction dynamics was analyzed and compared with experimental data. The ear structure model was calculated by frequency response method, and the influence of bacterial biofilm growth on the sound conduction in the artificial titanium ossicular was analyzed at the same time. Results the amplitudes of tympanic convexity and stapes floor were in agreement with the experimental data, and the correctness of the model was verified. The presence of biofilm can cause hearing loss of 0 ~ 1.6 dB in low frequency range, and biofilm growth along the radial direction of partial ossicular prosthesis will cause hearing loss of 0 ~ 12 dB at middle and high frequency, especially at 8 kHz, hearing loss is as high as 11.2 dB. Conclusion bacterial biofilm has an effect on hearing loss in low frequency range and increased in high frequency range. The radial growth of bacterial biofilm on the artificial ossicle will reduce hearing and affect the efficiency of artificial prosthesis to recover to normal hearing.
【作者单位】：上海大学土木工程系;复旦大学附属中山医院耳鼻喉科;
【基金】：国家自然科学基金项目(11072143,11272200,81170910)
【分类号】：R764

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