甲基强的松龙鼓室注射与全身应用治疗突发性聋的疗效比较

发布时间：2018-07-18 13:18

【摘要】：目的探讨鼓室注射甲基强的松龙联合改善微循环药物综合治疗突发性聋(突聋)的疗效。方法将270例单耳突聋患者分为A、B两组,A组(对照组)167例静脉滴注甲基强的松龙,B组(治疗组)103例鼓室注射甲基强的松龙,两组均静脉给予改善微循环药物联合治疗。每治疗一周后复查纯音听阈及多频声导抗,直到听力完全恢复正常或连续两周纯音听阈无明显变化,并查看鼓膜情况。随访1月~1年,比较两组疗效。结果 A组总有效率56.29%(94/167),B组总有效率61.17%(63/103),两组总有效率差异无统计学意义(P0.05)。A、B两组中,低中频听力下降患者有效率分别为78.12%(25/32)、85.71%(18/21),中高频听力下降患者有效率分别为52.38%(11/21)、69.23%(9/13),全频下降患者有效率分别为53.06%(52/98)、59.32%(35/59),全聋患者有效率分别为37.5%(6/16)、30%(3/10),差异均无统计学意义。随访1月~1年,听力稳定,鼓膜无穿孔及钙化斑。结论甲基强的松龙全身应用与鼓室注射治疗突聋疗效相当。
[Abstract]:Objective to investigate the effect of methylprednisolone injection in the treatment of sudden deafness. Methods 270 patients with mono-auricular deafness were divided into two groups: control group (n = 167), group B (n = 103) received methylprednisolone intravenously, and group B (n = 103) were treated by intravenous injection of methylprednisolone. After one week of treatment, pure tone hearing threshold and multi-frequency acoustic conductance were re-examined until the hearing completely returned to normal or the pure tone hearing threshold did not change for two consecutive weeks, and the tympanic membrane was examined. Patients were followed up for 1 month to 1 year to compare the efficacy of the two groups. Results the total effective rate of group A was 56.29% (94 / 167). The total effective rate of group B was 61.17% (63 / 103). The effective rates were 78.12% (25 / 32), 85.71% (18 / 21), 52.38% (11 / 21), 69.23% (9 / 13), 53.06% (5298), 59.32% (35 / 59), 37.5% (6/ 16) and 30% (310 / 13), respectively. Follow-up for 1 month to 1 year showed stable hearing and no perforation and calcification of tympanic membrane. Conclusion the efficacy of methylprednisolone in the treatment of sudden deafness is similar to that of tympanic injection.
【作者单位】：河北省唐山市协和医院耳鼻咽喉头颈外科;河北省唐山职业技术学院;
【分类号】：R764

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