MMP-2在喉鳞状细胞癌组织中的表达及其与预后的关系

发布时间：2018-07-21 22:12

【摘要】：目的:探讨基质金属蛋白酶2(MMP-2)作为潜在的对人喉鳞状细胞癌的预后因子的作用。方法:回顾性分析73例进行手术切除的患者肿瘤组织MMP-2的表达。免疫组织化学染色用链霉素抗生物素蛋白过氧化物酶复合法进行。术后随访观察MMP-2表达及临床病理特征,包括年龄、性别、临床分型、病理类型、淋巴结转移和预后之间的关系,均采用SPSS 19.0统计学软件分析。结果:73例患者MMP-2的阳性表达率为57.53%(42/73)。Kaplan-Meier分析显示MMP-2表达阴性组和表达阳性组间的5年总生存率分别为76.0%和57.5%,差异有统计学意义(P0.05)。原发灶部位、临床分期、淋巴结转移、T分级与喉癌预后相关(P分别为0.002、0.009、0.034、0.001);病理分化、年龄和性别等与喉癌预后没有统计学意义上的相关性。结论:MMP-2表达与较差的生存相关,可以考虑作为一个潜在的预后不良的标志物。
[Abstract]:Aim: to investigate the role of matrix metalloproteinase 2 (MMP-2) as a potential prognostic factor in human laryngeal squamous cell carcinoma. Methods: the expression of MMP-2 in tumor tissues of 73 patients undergoing surgical resection was analyzed retrospectively. Immunohistochemical staining was performed by streptomycin and biotin peroxidase complex method. The expression of MMP-2 and its clinicopathological features, including age, sex, clinical type, pathological type, lymph node metastasis and prognosis, were analyzed by SPSS 19.0 software. Results the positive expression rate of MMP-2 in 73 patients was 57.53% (42 / 73). Kaplan-Meier analysis showed that the 5-year overall survival rate was 76.0% and 57.5% in negative and positive groups of MMP-2, respectively. The difference was statistically significant (P0.05). The location of primary lesion, clinical stage, T grade of lymph node metastasis were correlated with the prognosis of laryngeal carcinoma (P = 0.002, 0.009, 0.034%, respectively), but the pathological differentiation, age and sex were not significantly correlated with the prognosis of laryngeal carcinoma. Conclusion the expression of MMP-2 is associated with poor survival and may be considered as a potential marker of poor prognosis.
【作者单位】：沈阳医学院附属中心医院耳鼻咽喉科;
【基金】：沈阳医学院科学研究基金(No:20111020)
【分类号】：R739.65

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