变应性鼻炎患者血清IL-12和IL-27的表达水平及其意义初探
发布时间：2018-07-31 07:19
【摘要】：目的：通过研究接受和未经免疫治疗的变应性鼻炎患者血清中IL-12和IL-27的水平,并分析IL-12和IL-27两者的相关性,探讨IL-12和IL-27在变应性鼻炎的发病机制和治疗中的作用。 方法：选择接受免疫治疗2年以上的变应性鼻炎患者20例为免疫治疗组,未经免疫治疗的变应性鼻炎患者20例为未治疗组,以20例无变态反应疾病的健康人为对照组。三组间年龄和性别均无显著差异,受检前二周内均未使用类固醇激素。对免疫治疗组和未治疗组的变应性鼻炎患者进行症状和体征评分。用ELISA法检测三组血清中IL-12和IL-27的水平。采用SPSS16.0统计软件进行统计分析。 结果：1.免疫治疗组的症状和体征记分(6.95±1.19)明显低于未治疗组(9.80±1.98),两者比较有统计学意义(P0.05)。2.IL-12水平：变应性鼻炎患者未治疗组、免疫治疗组和正常对照组的血清IL-12浓度分别为(111.82±41.32pg/ml)、(163.78±51.76pg/ml)和(207.28±73.90pg/ml),变应性鼻炎两组均显著低于正常对照组,未治疗组显著低于免疫治疗组,两两之间比较有统计学意义(P0.05)。3.IL-27水平：变应性鼻炎患者未治疗组、免疫治疗组和正常对照组的血清IL-27浓度分别为(287.72±1 07.97pg/m1)(403.85±155.59pg/ml)和(622.65±237.87pg/ml),变应性鼻炎两组均显著低于正常对照组,免疫治疗组血清IL-27浓度高于未治疗组,两两之间比较有统计学意义(P0.05)。4.IL-27和IL-12水平有一定正相关性(r=0.343)。 结论：1.变应性鼻炎患者血清中IL-12和IL-27水平显著低于正常人,表明IL-12和IL-27在变应性鼻炎的发病机制中起作用。2.经免疫治疗症状和体征获得改善的变应性鼻炎患者,血清中IL-12和IL-27水平显著高于未经治疗的患者,表明IL-12和IL-27可能在变应性鼻炎免疫治疗中发挥免疫调节作用。3.IL-27与IL-12在变应性鼻炎患者血清中的表达水平有一定正相关性,提示IL-27可能在变应性鼻炎的发病机制中与IL-12发挥相似的作用,IL-27有可能作为治疗变应性鼻炎的新靶点。
[Abstract]:Objective: to study the levels of IL-12 and IL-27 in serum of allergic rhinitis treated with or without immunotherapy, and to analyze the relationship between IL-12 and IL-27, and to explore the role of IL-12 and IL-27 in the pathogenesis and treatment of allergic rhinitis. Methods: twenty patients with allergic rhinitis who received immunotherapy for more than 2 years were selected as immunotherapy group, 20 patients with allergic rhinitis without immunotherapy as untreated group and 20 healthy persons without allergic disease as control group. There was no significant difference in age and sex among the three groups. The symptoms and signs of allergic rhinitis in immunotherapy group and untreated group were evaluated. The levels of IL-12 and IL-27 in serum of the three groups were detected by ELISA method. SPSS16.0 statistical software was used for statistical analysis. The result is 1: 1. The score of symptoms and signs in immunotherapy group (6.95 卤1.19) was significantly lower than that in untreated group (9.80 卤1.98). The serum IL-12 concentrations in immunotherapy group and normal control group were (111.82 卤41.32pg/ml), (163.78 卤51.76pg/ml) and (207.28 卤73.90pg/ml), respectively. The levels of serum IL-12 in allergic rhinitis group were significantly lower than those in normal control group, and those in untreated group were significantly lower than those in immunotherapy group. The levels of IL-27 in patients with allergic rhinitis were (287.72 卤1 07.97pg/m1) (403.85 卤155.59pg/ml) and (622.65 卤237.87pg/ml), respectively. The levels of IL-27 in patients with allergic rhinitis were (287.72 卤1 07.97pg/m1) and (622.65 卤237.87pg/ml), respectively. The levels of IL-27 in allergic rhinitis group were significantly lower than those in normal control group. The level of serum IL-27 in immunotherapy group was higher than that in untreated group (P0.05). 4. There was a positive correlation between IL-27 and IL-12 (r = 0.343). Conclusion 1. The serum levels of IL-12 and IL-27 in patients with allergic rhinitis were significantly lower than those in normal subjects, indicating that IL-12 and IL-27 play an important role in the pathogenesis of allergic rhinitis. The serum levels of IL-12 and IL-27 in allergic rhinitis patients with improved symptoms and signs after immunotherapy were significantly higher than those without treatment. These results suggest that IL-12 and IL-27 may play an immunomodulatory role in the immunotherapy of allergic rhinitis. 3. IL-27 is positively correlated with the expression of IL-12 in serum of patients with allergic rhinitis. It is suggested that IL-27 may play a similar role with IL-12 in the pathogenesis of allergic rhinitis. IL-27 may be a new target for the treatment of allergic rhinitis.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R765.21
本文编号：2154843
[Abstract]:Objective: to study the levels of IL-12 and IL-27 in serum of allergic rhinitis treated with or without immunotherapy, and to analyze the relationship between IL-12 and IL-27, and to explore the role of IL-12 and IL-27 in the pathogenesis and treatment of allergic rhinitis. Methods: twenty patients with allergic rhinitis who received immunotherapy for more than 2 years were selected as immunotherapy group, 20 patients with allergic rhinitis without immunotherapy as untreated group and 20 healthy persons without allergic disease as control group. There was no significant difference in age and sex among the three groups. The symptoms and signs of allergic rhinitis in immunotherapy group and untreated group were evaluated. The levels of IL-12 and IL-27 in serum of the three groups were detected by ELISA method. SPSS16.0 statistical software was used for statistical analysis. The result is 1: 1. The score of symptoms and signs in immunotherapy group (6.95 卤1.19) was significantly lower than that in untreated group (9.80 卤1.98). The serum IL-12 concentrations in immunotherapy group and normal control group were (111.82 卤41.32pg/ml), (163.78 卤51.76pg/ml) and (207.28 卤73.90pg/ml), respectively. The levels of serum IL-12 in allergic rhinitis group were significantly lower than those in normal control group, and those in untreated group were significantly lower than those in immunotherapy group. The levels of IL-27 in patients with allergic rhinitis were (287.72 卤1 07.97pg/m1) (403.85 卤155.59pg/ml) and (622.65 卤237.87pg/ml), respectively. The levels of IL-27 in patients with allergic rhinitis were (287.72 卤1 07.97pg/m1) and (622.65 卤237.87pg/ml), respectively. The levels of IL-27 in allergic rhinitis group were significantly lower than those in normal control group. The level of serum IL-27 in immunotherapy group was higher than that in untreated group (P0.05). 4. There was a positive correlation between IL-27 and IL-12 (r = 0.343). Conclusion 1. The serum levels of IL-12 and IL-27 in patients with allergic rhinitis were significantly lower than those in normal subjects, indicating that IL-12 and IL-27 play an important role in the pathogenesis of allergic rhinitis. The serum levels of IL-12 and IL-27 in allergic rhinitis patients with improved symptoms and signs after immunotherapy were significantly higher than those without treatment. These results suggest that IL-12 and IL-27 may play an immunomodulatory role in the immunotherapy of allergic rhinitis. 3. IL-27 is positively correlated with the expression of IL-12 in serum of patients with allergic rhinitis. It is suggested that IL-27 may play a similar role with IL-12 in the pathogenesis of allergic rhinitis. IL-27 may be a new target for the treatment of allergic rhinitis.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R765.21
【引证文献】
相关硕士学位论文 前1条
1 马艳;2%碳酸氢钠液对变应性鼻炎鼻黏膜的影响及IL-4、IL-10的表达[D];青海大学;2012年
，本文编号：2154843
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