螨过敏咽炎患者舌下脱敏的疗效及其影响因素分析

发布时间：2018-07-31 18:05

【摘要】：目的:评估舌下特异性免疫治疗(SLIT)螨过敏咽炎患者是否起效,探讨不同治疗方案、单一和多重过敏、性别等因素是否对SLIT起效有影响。方法:对我院53例螨过敏咽炎患者,进行治疗前和治疗6个月后的药物总评分(TMS)和治疗6个月后的患者自我疗效评价。根据给药方案将试验组分为SLIT组、综合组;根据点刺结果将试验组分为尘螨组和多重组;根据性别将试验组分为男性组和女性组。将25例仅接受对症药物治疗的患者作为对照组。将对照组和试验组以及试验组中不同各组在治疗6个月后的有效率和TMS减少比例进行比较。结果:试验组有效率和TMS减少比均高于对照组,差异有统计学意义(P0.01)。SLIT组有效率为72.73%,综合组为76.47%,两者差异无统计学意义(P0.05);尘螨组有效率和TMS减少比分别为61.54%和94.46%,多重组分别为66.67%和71.25%,2组有效率和TMS减少比比较,差异无统计学意义(P0.05);女性组有效率和TMS减少比分别为83.33%和97.04%,男性组分别为58.33%和66.67%,2组有效率差异无统计学意义(P0.05),而2组TMS减少比差异有统计学意义(P0.05)。结论:SLIT对螨过敏咽炎患者有效;治疗方案,单一和多重过敏对SLIT治疗螨过敏咽炎患者无影响,性别有一定影响。
[Abstract]:Objective: to evaluate whether sublingual specific immunotherapy for (SLIT) mite hypersensitive pharyngitis is effective, and to explore whether different therapeutic schemes, single and multiple allergies, and sex have influence on the SLIT response. Methods: 53 patients with hypersensitive pharyngitis of mite were evaluated by (TMS) before treatment and 6 months after treatment. The experimental group was divided into SLIT group and comprehensive group according to the drug administration scheme, the experimental group was divided into dust mites group and multiple recombination group according to the prick results, and the experimental group was divided into male and female groups according to sex. Twenty-five patients with symptomatic drug therapy were used as control group. The effective rate and the ratio of TMS reduction were compared between the control group and the experimental group and the different groups in the test group after 6 months of treatment. Results: the effective rate and TMS reduction ratio in the experimental group were higher than those in the control group. The difference was statistically significant (P0.01). The effective rate of SLIT group was 72.733.There was no significant difference between the two groups (P0.05), the effective rate and TMS reduction ratio of dust mite group were 61.54% and 94.46%, the effective rate of multiple recombination group were 66.67% and 71.25%, respectively. There was no significant difference (P0.05); the effective rate and TMS reduction ratio were 83.33% and 97.04 in female group, 58.33% and 66.67% in male group, respectively (P0.05), but there was significant difference in TMS reduction ratio between two groups (P0.05). Conclusion the treatment of hypersensitive pharyngitis patients with mites by SLIT is effective, and the single or multiple allergies have no effect on the treatment of hypersensitive pharyngitis by SLIT, and the sex has some influence on the patients with hypersensitive pharyngitis.
【作者单位】：安徽医科大学附属安庆医院;安庆市立医院耳鼻咽喉科;
【分类号】：R766.14

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