平均血小板容积与糖尿病视网膜病变严重程度的横断面研究

发布时间：2018-08-13 13:36

【摘要】：目的评估平均血小板容积(mean platelet volume,MPV)与糖尿病视网膜病变(diabetic retinopathy,DR)严重程度的关系。方法横断面研究。选取所有于2012年1月至2013年12月在我院眼科中心住院的DR患者137例(非增殖期67例,增殖期70例),同时选取72例无DR糖尿病患者和70例无糖尿病健康人群进行对照。收集人口学资料及疾病史,抽空腹血行MPV和血小板计数等检查。结果健康对照组人群MPV水平[7.2(5.6-9.9)fL]显著低于糖尿病各组(均为P0.05),且随DR病变分级的增加,MPV水平显著增加,分别为7.8(5.7-10.1)fL、8.3(5.5-11.0)fL和8.9(5.9-12.5)fL,差异均有统计学意义(均为P0.05)。Logistic回归分析显示,随着MPV水平升高,非增殖期(OR:1.382;95%CI:1.280-1.484)和增殖期DR(OR:1.481;95%CI:1.370-1.592)的患病风险显著增加(均为P0.001)。结论 MPV水平随DR严重程度增加而升高;随着MPV水平升高,非增殖期和增殖期DR患病风险增加。
[Abstract]:Objective to evaluate the relationship between mean platelet volume (mean platelet) and severity of diabetic retinopathy (Dr). Methods Cross-sectional study. From January 2012 to December 2013, 137 Dr patients (67 in non-proliferative phase and 70 in proliferative phase) in ophthalmology center of our hospital were selected, and 72 patients without Dr diabetes mellitus and 70 healthy people without diabetes mellitus were selected as control group. Demographic data and history of disease were collected, and MPV and platelet count were examined by emptying abdominal blood. Results the level of MPV in the healthy control group [7.2 (5.6-9.9) fL] was significantly lower than that in the diabetic group (P0.05), and it was significantly increased with the increase of Dr pathological grade (7.8 (5.7-10.1) fL8.3 (5.5-11.0) fL and 8.9 (5.9-12.5) fL, respectively. The difference was statistically significant (P0.05) .Logistic regression analysis showed that there was no significant difference between the two groups. With the increase of MPV level, the risk of non-proliferative stage (OR: 1.382) and proliferative phase Dr (OR 1.48195 CI: 1.370-1.592) increased significantly (all P0.001). Conclusion the level of MPV increases with the severity of Dr, and with the increase of MPV, the risk of Dr in non-proliferative and proliferative stages increases.
【作者单位】：西安市第四医院眼科;
【分类号】：R587.2;R774.1

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