声带白斑82例临床病理特征及预后分析

发布时间：2018-08-14 14:29

【摘要】：目的:探讨声带白斑的临床病理特征与影响声带白斑治疗预后的因素。方法:回顾性分析2008-01-2012-12期间我院收治的82例声带白斑患者的临床资料。分析患者性别、年龄、吸烟、饮酒、胃食管反流、病理类型与声带白斑复发以及癌变的关系。结果:82例声带白斑患者中,男76例,女6例;年龄30~90岁,中位年龄52岁。长期吸烟70例(85.37%),长期饮酒67例(81.71%),伴胃食管反流48例(58.54%);术后病理提示:黏膜慢性炎症8例(9.76%),鳞状上皮增生42例(51.22%),黏膜轻度异型增生14例(17.07%),中度异型增生8例(9.76%),重度异型增生10例(12.19%)。多因素分析表明,病理类型是影响声带白斑预后的独立危险因素(复发P0.05,OR=0.543;恶变P0.05,OR=0.382),且复发率及恶变率随异型增生严重程度而增加。结论:病理类型是声带白斑预后的重要指标,且预后随异型增生严重程度增加而变差,应密切随访。
[Abstract]:Objective: to investigate the clinicopathological features and prognostic factors of vocal cord leukoplakia. Methods: the clinical data of 82 patients with vocal cord leukoplakia in our hospital from January to December 2012 were retrospectively analyzed. The relationship between sex, age, smoking, alcohol consumption, gastroesophageal reflux, pathological type and recurrence of vocal cord leukoplakia and carcinogenesis was analyzed. Results among 82 patients with vocal cord leukoplakia, 76 were male and 6 female, with a median age of 52 years (30 ~ 90 years). Long-term smoking was found in 70 cases (85.37%), long-term drinking in 67 cases (81.71%), and gastroesophageal reflux in 48 cases (58.54%), pathological findings showed that chronic mucosal inflammation occurred in 8 cases (9.76%), squamous epithelium hyperplasia in 42 cases (51.22%), mild dysplasia in 14 cases (17.07%), moderate dysplasia in 8 cases (9.76%) and severe dysplasia in 10 cases (12.19%). Multivariate analysis showed that the pathological type was an independent risk factor for the prognosis of vocal cord leukoplakia (recurrent P0.05ORP 0.543; malignant change P0.05OR0.382), and the recurrence rate and malignancy rate increased with the severity of dysplasia. Conclusion: pathological type is an important indicator of the prognosis of vocal cord leukoplakia, and the prognosis of vocal cord leukoplakia becomes worse with the severity of dysplasia, which should be closely followed up.
【作者单位】：广东省人民医院广东省医学科学院耳鼻咽喉头颈外科;
【分类号】：R767.4

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