OSAHS患者正压通气治疗后促红细胞生成素及血液流变学的变化

发布时间：2018-08-16 13:55

【摘要】：目的观察中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者经无创正压通气(NPPV)治疗后血清促红细胞生成素(EPO)及血液流变学水平变化。方法选择40例诊断为中重度OSAHS患者(OSAHS组)和40例健康查体者(对照组),OSAHS组行NPPV治疗3个月,分别检测治疗前及治疗后1、3个月时血清EPO血常规、血液流变学指标,监测睡眠呼吸暂停低通气指数(AHI)、夜间平均最低血氧饱和度(LSaO2),对照组于相同时间点也进行上述指标检测。结果 OSAHS组与对照组各时间点血清EPO、血常规、血液流变学各指标、AHI、LSaO2经重复测量设计的方差分析组间、时间之间及组间与时间交互作用均有统计学意义;OSAHS组各指标均随治疗时间延长逐渐改善,对照组各指标均在正常范围。结论 OSAHS患者经NPPV治疗可以明显改善缺氧程度,降低血清EPO水平及血液黏度对于防治OSAHS及其并发症有重要临床意义。
[Abstract]:Objective to observe the changes of serum erythropoietin (EPO) and hemorheology in patients with moderate and severe obstructive sleep apnea hypopnea syndrome (OSAHS) treated with noninvasive positive pressure ventilation (NPPV). Methods 40 patients with moderate and severe OSAHS (OSAHS group) and 40 healthy controls (control group) were treated with NPPV for 3 months. Serum EPO blood routine and hemorheology were detected before treatment and 1 and 3 months after treatment, respectively. The nocturnal mean minimum oxygen saturation (LSaO2) of sleep apnea hypopnea index (AHI),) was monitored. Results the levels of serum EPO, blood routine and hemorheology in OSAHS group and control group were measured repeatedly. There was statistical significance between time and between groups and time interaction. The indexes of OSAHS group were improved gradually with the prolongation of treatment time, and that of control group were all in the normal range. Conclusion treatment with NPPV in patients with OSAHS can obviously improve the degree of hypoxia and reduce the level of serum EPO and blood viscosity. It is of great clinical significance to prevent and treat OSAHS and its complications.
【作者单位】：河北医科大学第一医院耳鼻咽喉头颈外科;
【基金】：河北省科学技术研究与发展计划项目(112761137)
【分类号】：R766

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