学龄前儿童单纯肥大扁桃体组织幽门螺杆菌感染及其临床意义

发布时间：2018-08-16 14:47

【摘要】：摘要 目的：检测幽门螺杆菌(Helipcobacter pylori, HP)在学龄前儿童单纯肥大的扁桃体组织中的感染情况,探讨HP在扁桃体肥大中的作用及其临床意义。 方法：收集单纯扁桃体肥大患儿手术摘除的扁桃体组织标本80例,同时收集同期住院手术治疗的儿童慢性扁桃体炎的扁桃体标本40例。采用免疫组化技术定性检测幽门螺杆菌在肥大扁桃体中的感染情况,对各组幽门螺杆菌感染情况进行对比研究。 结果：80例单纯肥大扁桃体中44例有HP表达,感染阳性率为55.0%；而在慢性扁桃体炎组40例中,有7例HP为阳性,感染率为17.5%。HP在单纯扁桃体肥大组的表达阳性率显著高于对照组,差异具有统计学意义(P0.05)。其中男性患儿HP感染率为55.7%,女性患儿为53.6%,两者差异无统计学意义(P＞0.05)。比较Ⅰ、Ⅱ、Ⅲ度肥大的扁桃体组织中HP感染率发现：Ⅱ度扁桃体肥大者HP感染率明显高于Ⅰ度扁桃体肥大组(P＜0.05),Ⅲ度肥大组HP明显高于其他两组(P＜0.05)。伴发分泌性中耳炎的肥大扁桃体组织HP感染率较单纯扁桃体肥大者高,且显著高于仅伴有腺样体肥大的患儿(P0.05)。 结论：HP感染可能在学龄前儿童单纯扁桃体肥大的发病机制中起着一定的作用,并影响分泌性中耳炎的发生与发展。
[Abstract]:Objective: to detect the infection of Helicobacter pylori (Helipcobacter pylori, HP) in simple hypertrophic tonsils of preschool children and to explore the role of HP in tonsil hypertrophy and its clinical significance. Methods: 80 cases of tonsillectomy and 40 cases of chronic tonsillitis in children with simple tonsillar hypertrophy were collected. The infection of Helicobacter pylori in hypertrophic tonsils was detected qualitatively by immunohistochemical technique, and the infection of Helicobacter pylori in each group was compared. Results HP was expressed in 44 of 80 cases of simple hypertrophic tonsils, and the positive rate of infection was 55.0%, while in 40 cases of chronic tonsillitis, 7 cases were HP positive. The positive rate of 17.5%.HP expression in simple tonsil hypertrophy group was significantly higher than that in control group. The difference was statistically significant (P0.05). The infection rate of HP was 55.7% in male and 53.6% in female. There was no significant difference between the two groups (P > 0.05). The HP infection rate in the tonsils with degree 鈪，

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