糖尿病患者血清瘦素、脂联素水平与糖尿病视网膜病变不同分期的相关性研究

发布时间：2018-08-27 13:11

【摘要】：目的探讨血清瘦素、脂联素水平与糖尿病视网膜病变的关系。方法收集河北联合大学附属医院院内分泌科住院的2型糖尿病患者120例,将其分为增殖性视网膜病变组38例,非增殖性视网膜病变组42例,糖尿病无视网膜病变组40例,另设健康对照者40例。采用放射免疫法测定血浆瘦素水平,采用酶联免疫(ELISA)定量测定脂联素水平,并于生化室检验空腹血糖、餐后2 h血糖、糖化血红蛋白、胆固醇、三酰甘油。结果病例组包括增殖性视网膜病变组、非增殖性视网膜病变组、糖尿病无视网膜病变组与对照组。血浆瘦素分别为(18.42±4.81)μg/L、(14.31±5.76)μg/L、(10.51±3.34)μg/L、(4.1±2.4)μg/L;血浆脂联素平分别为(1.34±0.75)μg/ml、(3.45±1.53)μg/ml、(5.96±1.99)μg/ml、(7.89±2.33)μg/ml。各病例组与对照组比较差异均有统计学意义(P0.01);各病例组组间比较均差异有统计学意义(P0.01);血浆瘦素水平与年龄、空腹血糖、餐后2h血糖、糖化血红蛋白、胆固醇、三酰甘油等无相关关系。直线相关分析表明:血浆瘦素水平与体重指数呈正相关。血清瘦素、脂联素水平与视网膜病变的相关性分析,随着DM病程的延长及视网膜受损程度与瘦素水平呈正相关(F=0.543,P0.01),与脂联素水平呈正负相关(F=0.428,P0.01)。结论血浆瘦素、脂联素水平是2型糖尿病视网膜病变发病的一种独立危险因子,且血浆瘦素增高的幅度与病情的严重程度正相关,脂联素水平减低的幅度与病情的严重程度负相关。为糖尿病视网膜病变的早期干预治疗提供了新思路。
[Abstract]:Objective to investigate the relationship between serum leptin and adiponectin levels and diabetic retinopathy. Methods 120 patients with type 2 diabetes were divided into proliferative retinopathy group (n = 38), non-proliferative retinopathy group (n = 42) and diabetic non-retinopathy group (n = 40). There were 40 healthy controls. Plasma leptin levels were measured by radioimmunoassay and adiponectin levels were measured by enzyme linked immunosorbent assay (ELISA). Fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, cholesterol and triacylglycerol were measured in biochemical laboratory. Results the cases included proliferative retinopathy group, non proliferative retinopathy group, diabetic non-retinopathy group and control group. Plasma leptin was (18.42 卤4.81) 渭 g / L, (14.31 卤5.76) 渭 g / L, (10.51 卤3.34) 渭 g / L, (4.1 卤2.4) 渭 g / L, and plasma adiponectin level was (1.34 卤0.75) 渭 g / ml, (3.45 卤1.53) 渭 g / ml, (5.96 卤1.99) 渭 g / ml, (7.89 卤2.33) 渭 g / ml, respectively. The difference between each case group and control group was statistically significant (P0.01), the difference between each case group was statistically significant (P0.01), plasma leptin level and age, fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, cholesterol, There was no correlation between triacylglycerol and so on. Linear correlation analysis showed that plasma leptin level was positively correlated with BMI. The correlation between serum leptin and adiponectin levels and retinopathy was positively correlated with the duration of DM and the degree of retinal damage (F0. 543, P0.01), and negatively correlated with adiponectin (F0. 428, P0. 01). Conclusion Plasma leptin and adiponectin levels are independent risk factors for the pathogenesis of type 2 diabetic retinopathy, and the extent of plasma leptin increase is positively correlated with the severity of the disease. The extent of decrease in adiponectin levels was negatively correlated with the severity of the disease. It provides a new idea for early intervention treatment of diabetic retinopathy.
【作者单位】：河北联合大学附属医院内分泌科;河北联合大学公共卫生学院;
【分类号】：R587.2;R774.1

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