甲状腺相关眼病患者干眼症患病率及特征分析

发布时间：2018-08-28 06:07

【摘要】：目的探讨甲状腺相关眼病(thyroid associated ophthalmopathy,TAO)患者干眼症的患病率及不同时期干眼症患病率的差异和特征。方法收集2014年1月至2014年12月281例TAO患者的资料,包括症状、泪液分泌试验(Schirmer I test,SIt)、泪膜破裂时间(break-up time,BUT)及角膜荧光素染色(fluorescent staining,FS)的结果。按照TAO临床活动度评分(clinical activity score,CAS),将患者分为活动期(CAS≥4分)和非活动期(CAS4分),根据TAO病程将患者分为短病程组(1 a)、中病程组(≥1~2 a)、长病程组(≥2 a)。分析干眼症患病率及特征。结果本组281例TAO患者干眼症患病率65.48%。活动期和非活动期干眼症患病率分别为77.08%和59.46%(χ2=8.685,P=0.003),SIt、BUT及FS评分差异均有统计学意义(均为P0.05)。短病程组和长病程组干眼症患病率分别为68.89%和50.91%(χ2=5.961,P=0.015),病程越长FS评分越小,FS评分差异有统计学意义(P0.05),但SIt及BUT组间差异均无统计学意义(均为P0.05)。结论 TAO患者干眼症患病率高,活动期和非活动期、不同病程时期患病率存在差异。病程在2 a以上者干眼症患病率降低。
[Abstract]:Objective to investigate the prevalence and characteristics of dry eye disease (thyroid associated ophthalmopathy,TAO) in patients with thyroid associated ophthalmopathy. Methods data of 281 patients with TAO from January 2014 to December 2014 were collected, including symptoms, tear secretion test (Schirmer I test,SIt), lacrimal film rupture time (break-up time,BUT) and corneal fluorescein staining (fluorescent staining,FS). According to TAO's clinical activity score (clinical activity score,CAS), patients were divided into active period (CAS 鈮，

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