硅油作为玻璃体腔填充物其眼内抑菌作用的研究

发布时间：2018-09-07 16:21

【摘要】： 目的:探讨硅油作为玻璃体腔填充物其对眼内炎的影响,及硅油是否具有抗微生物特性。方法:新西兰大白兔30只,其中29只随机分为两组,对照组为玻璃体切割术、实验组为玻璃体切割+硅油注入术。治疗后在不同时间点行临床观察,记录角膜混浊程度、前房炎症反应、玻璃体及视网膜的情况,21天时抽取各动物术眼前房水0.1ml进行细菌培养,后再摘除眼球行组织病理学检查。对临床炎症、组织病理学评分,和细菌培养阳性率进行数据统计,数据处理采用SPSS12.0统计软件,两组之间临床炎症评分与组织病理学评分的比较采用秩和检验,细菌培养阳性率采用Χ2检验。结果:①在角膜混浊程度和前房炎症反应的情况中,实验组均比对照组反应轻。②在角膜、前房及视网膜组织病理学分级情况中,实验组比对照组的情况良好。③两组的细菌培养阳性率均为零。结论:①单纯玻璃体切割术和玻璃体切割联合硅油填充术均对感染性眼内炎有一定的治疗作用②玻璃体切割联合硅油注入术疗效优于单纯玻璃体切割术。③硅油作为玻璃体腔填充物具有抗微生物。
[Abstract]:Aim: to investigate the effect of silicone oil as a glass filler on endophthalmitis and whether silicone oil has antimicrobial properties. Methods: thirty New Zealand white rabbits were randomly divided into two groups: the control group was vitrectomy and the experimental group was vitrectomy silicone oil injection. After treatment, clinical observation was performed at different time points to record the degree of corneal opacification, anterior chamber inflammation and vitreous and retinal conditions. The 0.1ml of anterior chamber water of all animals were extracted for bacterial culture at 21 days after treatment, and histopathological examination was performed after extirpation of the eyeball. The clinical inflammation, histopathological score and the positive rate of bacterial culture were statistically analyzed. The data were processed by SPSS12.0 software, and the clinical inflammation score and histopathological score were compared by rank sum test between the two groups. The positive rate of bacterial culture was tested by X 2 test. Results in the cases of corneal opacity and inflammation in anterior chamber, the reaction in the experimental group was less than that in the control group, and in the corneal, anterior chamber and retinal histopathological grading. The positive rate of bacterial culture in the two groups was zero. Conclusion both vitrectomy and vitrectomy combined with silicone oil implantation are effective in the treatment of infective endophthalmitis. 2 the curative effect of vitrectomy combined with silicone oil injection is superior to that of vitrectomy alone. 3 silicone oil is better than vitrectomy alone in the treatment of infective endophthalmitis. As a glass cavity filler, it has antimicrobial properties.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R779.6

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