ECCE与Phaco对角膜内皮细胞及角膜中央厚度影响的系统评价
发布时间：2018-09-09 13:37
【摘要】：目的系统评价白内障囊外摘除术与超声乳化吸出术对角膜内皮细胞及角膜中央厚度的影响。方法按Cochrane系统评价方法,计算机检索MEDLINE (1966～2010.11). EMbase (1980-2010.11)、Cochrane图书馆(2008年3期)和中国生物医学文献数据库(CBM,1979～2010.11),并手工检索相关会议文献。文献语种限制为中英文。收集所有相关随机对照试验,采用RevMan 5.0软件进行Meta分析。结果共纳入4篇随机对照试验,包括704例患者(共704只患眼),随访1～12个月。Meta分析结果显示：白内障囊外摘除术与白内障超声乳化吸出术在术后角膜内皮细胞计数方面[WMD=55.26,95%CI(0.79,109.73)],P=0.05,及在术后角膜中央厚度方面[WMD=28.21,95%CI(12.29,44.13)],P=0.0005,有差异。结论与白内障囊外摘除术相比,白内障超声乳化吸出术术后角膜内皮细胞计数减少更多,角膜中央厚度增加更多。因本系统评价纳入研究病例数较少,上述结论需更多设计严谨大样本随机对照试验加以验证。
[Abstract]:Objective to evaluate the effects of extracapsular cataract extraction and phacoemulsification on corneal endothelium and central corneal thickness. Methods according to the evaluation method of Cochrane system, MEDLINE (1966 / 2010.11) was searched by computer. EMbase (1980-2010.11) includes the Cochrane Library (3 issues 2008) and the Chinese Biomedical Literature Database (CBM,1979~2010.11). The language of the literature is restricted to Chinese and English. All the related randomized controlled trials were collected and Meta analysis was carried out with RevMan 5.0 software. Results A total of 4 randomized controlled trials were conducted. In 704 patients (704 eyes), the results of meta-analysis showed that extracapsular cataract extraction and phacoemulsification [WMD=55.26,95%CI _ (0.79109.73)] P0. 05, and corneal central thickness after cataract extraction and phacoemulsification. The degree of WMD=28.21,95%CI (12.29 ~ 44.13) was 0.0005. Conclusion compared with extracapsular cataract extraction, the number of corneal endothelium and the central thickness of cornea after phacoemulsification were decreased more and more. Due to the small number of cases included in this systematic evaluation, the above conclusions need to be verified by more well-designed randomized controlled trials with large samples.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R779.66
本文编号：2232537
[Abstract]:Objective to evaluate the effects of extracapsular cataract extraction and phacoemulsification on corneal endothelium and central corneal thickness. Methods according to the evaluation method of Cochrane system, MEDLINE (1966 / 2010.11) was searched by computer. EMbase (1980-2010.11) includes the Cochrane Library (3 issues 2008) and the Chinese Biomedical Literature Database (CBM,1979~2010.11). The language of the literature is restricted to Chinese and English. All the related randomized controlled trials were collected and Meta analysis was carried out with RevMan 5.0 software. Results A total of 4 randomized controlled trials were conducted. In 704 patients (704 eyes), the results of meta-analysis showed that extracapsular cataract extraction and phacoemulsification [WMD=55.26,95%CI _ (0.79109.73)] P0. 05, and corneal central thickness after cataract extraction and phacoemulsification. The degree of WMD=28.21,95%CI (12.29 ~ 44.13) was 0.0005. Conclusion compared with extracapsular cataract extraction, the number of corneal endothelium and the central thickness of cornea after phacoemulsification were decreased more and more. Due to the small number of cases included in this systematic evaluation, the above conclusions need to be verified by more well-designed randomized controlled trials with large samples.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R779.66
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