基质金属蛋白酶-2和血管内皮生长因子在喉癌中的表达及意义

发布时间：2018-09-14 16:04

【摘要】：目的探讨基质金属蛋白酶-2(MMP-2)和血管内皮生长因子(VEGF)在喉癌中的表达情况及临床意义。方法在全自动图像分析仪下采用免疫组化方法分别检测经临床及病理证实的54例喉癌、23例声带息肉和15例喉部正常黏膜组织的MMP-2、VEGF表达情况。结果喉癌组织中MMP-2的表达率为72.22%(39/54),与声带息肉(47.83%)和喉部正常黏膜组织(40.00%)比较,差异有统计学意义(P0.05)。VEGF在喉癌中的表达率为70.37%(38/54),与声带息肉(39.13%)和喉部正常黏膜组织(46.67%)比较,差异有统计学意义(P0.05)。MMP-2、VEGF的表达与喉癌的临床分期、淋巴结转移及浸润深度均有一定相关性。结论 MMP-2和VEGF可能共同参与喉癌的浸润和转移,与肿瘤的侵袭性生长有一定的关系。
[Abstract]:Objective to investigate the expression and clinical significance of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in laryngeal carcinoma. Methods Immunohistochemical method was used to detect the expression of MMP-2,VEGF in 23 cases of vocal cord polyps and 15 cases of normal laryngeal mucosa, which were confirmed by clinic and pathology. Results the expression rate of MMP-2 in laryngeal carcinoma was 72.22% (39 / 54), which was significantly higher than that in vocal cord polyp (47.83%) and normal laryngeal mucosa (40.00%) (P0.05). The expression rate of MMP-2 was 70.37% (38 / 54) in laryngeal carcinoma, 39.13% in vocal cord polyp and 46.67% in normal laryngeal mucosa. The difference was statistically significant (P0.05). The expression of MMP-2VEGF was correlated with the clinical stage, lymph node metastasis and depth of invasion of laryngeal carcinoma. Conclusion MMP-2 and VEGF may be involved in the invasion and metastasis of laryngeal carcinoma, and may be related to the invasive growth of the tumor.
【作者单位】：昆明医科大学第二附属医院耳鼻咽喉科;昆明医科大学第二附属医院病案统计科;四川大学华西医院耳鼻咽喉头颈外科;昆明医科大学公共卫生学院;
【基金】：云南省教育厅科学研究基金资助项目(2011C077) 昆明医学院第二附属医院联邦中青年医药师培养基金资助项目(2011-LB-01)
【分类号】：R739.65

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