中晚期喉癌颈淋巴结转移规律相关因素分析

发布时间：2018-09-17 07:37

【摘要】：目的总结T2~T4喉癌颈淋巴结转移规律,并分析其相关因素,探讨T2~T4喉癌颈淋巴结处理规范。方法回顾2002-12-16-2013-01-07首都医科大学附属北京同仁医院401例行喉部开放性手术治疗的T2~T4NXM0喉癌患者,应用Logistic回归分析喉癌淋巴结转移相关因素,Cox回归分析喉癌死亡危险因素,研究其颈淋巴结转移规律及相关因素。结果本组中晚期喉癌颈淋巴结总体转移24.4%(98/401)。Logistic回归分析结果提示,T分级(P=0.014)、喉癌分型(P=0.001)及病理(P=0.009)分级是喉癌淋巴结转移的相关因素,Ⅱ、Ⅲ、Ⅳ和ⅡB区的隐性转移率分别为17.2%(69/401)、16.7%(67/401)、2.5%(10/401)和1.5%(6/401)。全组1、3和5年生存率分别为98%、83%和79%。Cox回归分析发现,淋巴结转移(P0.001)与T分级(P=0.001)是喉癌死亡的危险因素,而喉癌分型对于喉癌预后影响差异无统计学意义。结论喉癌颈部淋巴结转移的发生与肿瘤的分型、T分级有关,不同分型喉癌的颈淋巴结转移区域有一定规律性,颈淋巴结转移是导致喉癌死亡的重要因素之一,应根据喉癌的不同分型和T分级处理颈淋巴结。
[Abstract]:Objective to summarize the law of cervical lymph node metastasis in T2~T4 laryngeal carcinoma and analyze its related factors and discuss the management criteria of cervical lymph node in T2~T4 laryngeal carcinoma. Methods T2~T4NXM0 laryngeal cancer patients who were treated with open laryngeal surgery at Tongren Hospital affiliated to Capital Medical University from December 2002 to July 2013-01-07 were retrospectively reviewed. Logistic regression analysis was used to analyze the risk factors associated with lymph node metastasis of laryngeal carcinoma and the risk factors of laryngeal cancer death. To study the law of cervical lymph node metastasis and related factors. Results the results of logistic regression analysis showed that T grade (P0. 014), laryngeal carcinoma classification (P0. 001) and pathological grade (P0. 009) were related factors of lymph node metastasis. The recessive metastasis rates of 鈪，

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