维生素D3鼻腔给药对变应性鼻炎患者鼻部症状的影响

发布时间：2018-09-19 18:01

【摘要】：目的:探讨维生素D3鼻腔给药对变应性鼻炎(AR)患者鼻痒、喷嚏、清涕、鼻塞等鼻部症状的影响。方法:选取皮肤点刺试验(SPT)阳性的AR患者30例,SPT阴性的单纯鼻中隔偏曲患者30例,经鼻腔滴入维生素D3 30万IU,用分值法评估鼻部症状及给药前后变化。结果:SPT阳性的AR患者组经鼻腔滴入维生素D3前血清25-羟维生素D3浓度为(16.36±5.72)μg/L,给药后血清25-羟维生素D3浓度为(118.02±25.76)μg/L,给药前后血清25-羟维生素D3浓度差异有统计学意义(P0.01);SPT阳性的AR患者组经鼻腔滴入维生素D3前鼻痒、喷嚏、清涕、鼻塞评分分别为(1.53±0.80)、(1.12±0.70)、(1.06±0.83)、(1.18±0.64)分,给药后鼻痒、喷嚏、清涕、鼻塞评分分别为(0.76±0.75)、(0.41±0.62)、(0.35±0.50)、(0.35±0.70)分,给药前后鼻痒、喷嚏、清涕、鼻塞评分差异有统计学意义(P0.05);SPT阴性的单纯鼻中隔偏曲患者经鼻腔滴入维生素D3前后鼻痒、喷嚏、清涕及鼻塞评分差异无统计学意义(P0.05)。结论:维生素D3能经鼻腔黏膜很好吸收进入体内;维生素D3可以改善AR患者鼻部症状,补充维生素D3可能成为预防和治疗AR的辅助疗法。
[Abstract]:Objective: to investigate the effects of vitamin D 3 nasal administration on nasal symptoms in patients with allergic rhinitis (AR), such as nasal itch, sneeze, snot and nasal congestion. Methods: 30 AR patients with (SPT) positive skin prick test were selected. The nasal symptoms and changes before and after administration of vitamin D 3.3 million IU, were evaluated by nasal instillation of vitamin D 3.3 million IU,. Results the serum concentration of 25-hydroxyvitamin D _ 3 was (16.36 卤5.72) 渭 g / L in the AR group with positive AR before nasal drip, and the concentration of serum 25-hydroxyvitamin D _ 3 was (118.02 卤25.76) 渭 g / L after administration. There was significant difference in the concentration of 25-hydroxyvitamin D _ 3 before and after administration (P0.01). The patients with positive AR had nasal itching before dropping vitamin D3 through nasal cavity. The scores of sneezing, snot and nasal congestion were (1.53 卤0.80), (1.12 卤0.70), (1.06 卤0.83), (1.18 卤0.64), the scores of nasal itching, sneezing, snot and nasal congestion were (0.76 卤0.75), (0.41 卤0.62), (0.35 卤0.50), (0.35 卤0.70), respectively. The difference of nasal congestion score was statistically significant (P0.05). There was no significant difference in nasal itch, sneeze, snot and nasal congestion score between the patients with negative SPT and simple nasal septum deviation before and after vitamin D _ 3 dripping (P0.05). Conclusion: vitamin D 3 can be absorbed into the body through nasal mucosa and vitamin D 3 can improve nasal symptoms in patients with AR. Vitamin D 3 supplementation may be an adjuvant therapy for the prevention and treatment of AR.
【作者单位】：上海市徐汇区大华医院耳鼻咽喉科;上海市徐汇区中心医院;上海市徐汇区大华医院检验科;
【基金】：上海市卫生局科研课题(No:20114154)
【分类号】：R765.21

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