雷珠单抗联合Ahmed青光眼阀植入术治疗新生血管性青光眼

发布时间：2018-10-05 15:15

【摘要】：目的观察玻璃体腔注射雷珠单抗联合Ahmed青光眼阀植入术对新生血管性青光眼的治疗效果。方法选择药物无法控制眼压的新生血管性青光眼患者18例18眼,先给予患眼玻璃体腔注射雷珠单抗0.05 mL,于注药1周后行Ahmed青光眼阀植入术,并于术后及时行眼底荧光血管造影及视网膜激光光凝术。结果注药后2~7 d,16眼新生血管全部消退,2眼残留少许血管。玻璃体腔注药前眼压为38.0~59.0(48.5±9.5)mmHg(1 kPa=7.5 mmHg),注药后1周眼压为36.5~59.0(47.8±11.3)mmHg,注药前后眼压变化差异无统计学意义(P0.05)。青光眼阀植入术后随访1 a,14例患者眼压控制在正常范围,4例患者眼压出现不同程度升高。青光眼阀植入术前后眼压变化差异有统计学意义(P0.01)。青光眼阀植入术后视力提高者8例,视力无明显变化者10例。结论玻璃体腔注射雷珠单抗联合Ahmed青光眼阀植入术治疗新生血管性青光眼安全有效。
[Abstract]:Objective to observe the effect of vitreous injection of Leizhu McAb and Ahmed glaucoma valve implantation on neovascular glaucoma. Methods 18 patients (18 eyes) with neovascular glaucoma whose intraocular pressure could not be controlled by drugs were treated with Ahmed glaucoma valve implantation after intravitreal injection of Lei Zhu McAb for 0. 05 mL,. Fundus fluorescein angiography and retinal laser photocoagulation were performed immediately after operation. Results the neovascularization disappeared completely in 2 eyes 7 days after injection and a few vessels remained in 2 eyes. The intraocular pressure (IOP) before and after intravitreous injection was 38.0) mmHg (48.5 卤9.5) mmHg (1 kPa=7.5 mmHg),) and the intraocular pressure was 36.5 卤59.0 (47.8 卤11.3) mmHg,. There was no significant difference in intraocular pressure before and after intravitreous injection (P0.05). The IOP of 14 patients with glaucoma valve implantation was controlled within normal range in 4 patients. There was significant difference in intraocular pressure before and after glaucoma valve implantation (P 0.01). After glaucoma valve implantation, visual acuity was improved in 8 cases and no obvious change in visual acuity in 10 cases. Conclusion it is safe and effective to treat neovascular glaucoma by intravitreal injection of Lei Zhu McAb and Ahmed glaucoma valve implantation.
【作者单位】：深圳爱视眼科专科门诊部;深圳市罗湖区人民医院眼科;中山大学中山眼科中心眼科学国家重点实验室;
【基金】：广东省医学科研基金(编号:B2013139) 佛山市医学类科技攻关项目(编号:201308098)~~
【分类号】：R779.6

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