回弹式眼压计在正常人群眼压测量中的临床应用研究
发布时间：2018-10-08 08:20
【摘要】： 目的：研究回弹式眼压计(Rebound tonometer, RT) Icare (Icare rebound tonometer, Icare)及IOPen (IOPen tonometer, IOPen)在正常人群眼压测量中的准确性及可靠性,以及与中央角膜厚度(central corneal thickness,CCT)的相关性。 方法：收集2009年3月至2009年5月在我院门诊就诊的124例正常人的244只眼,随机采用Icare回弹式眼压计(Icare)、IOPen回弹式眼压计(IOPen)测量眼压后,再用Goldmann压平式眼压计(Goldmann applanation tonometry,GAT)测量眼压值,随后用超声角膜测厚仪(Pachymeter,SP-3000,TOMEY,Japan)测量中央角膜厚度(CCT),比较Icare、IOPen及GAT三种眼压计的测量结果,进行描述性分析,同时将三组眼压值分别与CCT进行相关性分析。 结果：124例受检者的年龄为16～76岁,平均年龄为40.22±14.47岁。Icare测得的眼压平均值为15.46±3.52mmHg, IOPen测得的眼压平均值为13.05±3.59mmHg, GAT测得的眼压平均值为15.64±2.57mmHg, IOPen测量值明显低于Icare与GAT测量值。经Wilcoxon配对秩检验,Icare与GAT的眼压测量值之间的平均差异为-0.19±2.68mmHg,差异无统计学意义(Z=-1.193,P=0.2330.05)；IOPen与GAT的眼压测量值之间的平均差异为-2.60±4.17mmHg,差异有极显著统计学意义(Z=-8.437,P=0.0000.01)。在一致性分析中,Icare与GAT差值的均值为-0.2mmHg,标准差为2.68mmHg,95%的一致性界限为(-5.4～5.1) mmHg;在一致性界限范围内,Icare与GAT的眼压测量值相比,差值的绝对值最大为5.4mmHg;差异分布频率显示Icare与GAT的差值84%在±3mmHg范围内,68%的差异值在±2mmHg范围内,47%的差异值在±1mmHg范围内。IOPen与GAT差值的均值为-2.6mmHg,标准差为4.17mmHg,95%的一致性界限为(-10.8～5.6)mmHg,在一致性界限范围内,IOPen与GAT的眼压测量值相比,差值的绝对值最大为10.8mmHg。差异分布频率显示IOPen与GAT的差值49%在±3mmHg范围内,34%的差异值在±2mmHg范围内,16%的差异值在1mmHg范围内。Icare与GAT之间存在直线相关关系,且呈正相关性(rs=0.656,p0.01); IOPen与GAT之间无直线相关关系(rs=0.122,p0.05)。CCT的平均值为539.90±31.85μm。Icare, GAT与CCT之间均呈正相关,相关系数分别为0.382(p0.01)和0.342 (p0.01)。IOPen与CCT之间无直线相关关系(rs=-0.073,P0.05)。Icare与GAT差值与CCT之间有直线相关关系且两者呈正相关(rs=0.180,P0.01),即角膜越厚,Icare与GAT差值越大。CCT每增加10μm, Icare与GAT差值则增加0.17mmHg。 结论：Icare与GAT的眼压测量值之间具有很好的相关性和一致性,Icare眼压计既容易操作又无需表面麻醉,但其测量值仍然受中央角膜厚度的影响,所以临床实践中要考虑CCT对Icare测量结果的影响,这样才能更加准确地反映真实的眼压值。而IOPen测量眼压的准确性稍差。
[Abstract]:Objective: to study the accuracy and reliability of (Rebound tonometer, RT) Icare (Icare rebound tonometer, Icare) and IOPen (IOPen tonometer, IOPen) in the measurement of intraocular pressure (IOP) in normal subjects and its correlation with central corneal thickness (central corneal thickness,CCT). Methods: from March 2009 to May 2009, 244 eyes of 124 normal subjects who were treated in our hospital from March 2009 to May 2009 were collected. The intraocular pressure was measured by (Icare) rebound IOPen intraocular pressure meter (IOPen) and then measured by Goldmann flat intraocular pressure meter (Goldmann applanation tonometry,GAT). Then the central corneal thickness (CCT),) was measured by ultrasound keratometer (Pachymeter,SP-3000,TOMEY,Japan). The results of Icare,IOPen and GAT were compared, and the correlation between IOP and CCT was analyzed. Results the mean IOP measured by care was 15.46 卤3.52mmHg, the IOP by IOPen was 13.05 卤3.59mmHg, and the IOP measured by GAT was 15.64 卤2.57mmHg.The IOPen value was significantly lower than that of Icare and GAT, and the mean age of 1: 124 subjects was 16 ~ 76 years, and the mean age was 40.22 卤14.47 years old. The IOP measured by IOPen was 15.05 卤3.59mmHg, and the IOP measured by GAT was 15.64 卤2.57mmHg. IOPen was significantly lower than that measured by Icare and GAT. The average difference between IOP measured by Wilcoxon pair rank test and GAT was -0.19 卤2.68 mmHg, and there was no significant difference between IOP and IOP measured by GAT. The average difference was -2.60 卤4.17mmHg, and the difference was statistically significant (Z-8.437P0. 0000.01). In the consistency analysis, the average value of the difference between GAT and Icare is -0.2mmHg, and the standard deviation is 2.68mm Hgg 95%. The consistency limit of (-5.45.1) mmHg; is compared with the IOP measured by GAT within the range of consistency. The maximum absolute value of the difference is 5.4 mm Hg.The frequency of the difference distribution shows that the difference between Icare and GAT is 84% in 卤3mmHg range, and the difference value is 47% in 卤2mmHg range. The mean value of the difference between GAT and Icare is -2.6 mmHg, and the standard deviation is 4.17mmHg95%. The limit of (-10.8 ~ 5. 6) mmHg, was compared with the intraocular pressure measurements of GAT within the range of consistency limits. The absolute value of the difference is 10.8mmHg. The difference between IOPen and GAT was 49% in 卤3mmHg range, 34% in 卤2mmHg range and 16% in 卤2mmHg range. There was a linear correlation between 1mmHg and GAT. There was no linear correlation between rs=0.656,p0.01); IOPen and GAT (rs=0.122,p0.05). The average value of CCT was 539.90 卤31.85 渭 m.Icare.There was a positive correlation between GAT and CCT. The correlation coefficients were 0.382 (p0.01) and 0.342 (p0.01). IOPen had no linear correlation with CCT (rs=-0.073,P0.05). The difference between GAT and GAT was positively correlated with CCT (rs=0.180,P0.01). Conclusion there is a good correlation and consistency between the intraocular pressure measurements of GAT and that of the GAT. The IOP is easy to operate and needs no surface anesthesia, but the measured value is still affected by the central corneal thickness. Therefore, the effect of CCT on the results of Icare measurement should be considered in clinical practice, so that the true IOP can be more accurately reflected. The accuracy of intraocular pressure measured by IOPen was slightly poor.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R77
本文编号：2256079
[Abstract]:Objective: to study the accuracy and reliability of (Rebound tonometer, RT) Icare (Icare rebound tonometer, Icare) and IOPen (IOPen tonometer, IOPen) in the measurement of intraocular pressure (IOP) in normal subjects and its correlation with central corneal thickness (central corneal thickness,CCT). Methods: from March 2009 to May 2009, 244 eyes of 124 normal subjects who were treated in our hospital from March 2009 to May 2009 were collected. The intraocular pressure was measured by (Icare) rebound IOPen intraocular pressure meter (IOPen) and then measured by Goldmann flat intraocular pressure meter (Goldmann applanation tonometry,GAT). Then the central corneal thickness (CCT),) was measured by ultrasound keratometer (Pachymeter,SP-3000,TOMEY,Japan). The results of Icare,IOPen and GAT were compared, and the correlation between IOP and CCT was analyzed. Results the mean IOP measured by care was 15.46 卤3.52mmHg, the IOP by IOPen was 13.05 卤3.59mmHg, and the IOP measured by GAT was 15.64 卤2.57mmHg.The IOPen value was significantly lower than that of Icare and GAT, and the mean age of 1: 124 subjects was 16 ~ 76 years, and the mean age was 40.22 卤14.47 years old. The IOP measured by IOPen was 15.05 卤3.59mmHg, and the IOP measured by GAT was 15.64 卤2.57mmHg. IOPen was significantly lower than that measured by Icare and GAT. The average difference between IOP measured by Wilcoxon pair rank test and GAT was -0.19 卤2.68 mmHg, and there was no significant difference between IOP and IOP measured by GAT. The average difference was -2.60 卤4.17mmHg, and the difference was statistically significant (Z-8.437P0. 0000.01). In the consistency analysis, the average value of the difference between GAT and Icare is -0.2mmHg, and the standard deviation is 2.68mm Hgg 95%. The consistency limit of (-5.45.1) mmHg; is compared with the IOP measured by GAT within the range of consistency. The maximum absolute value of the difference is 5.4 mm Hg.The frequency of the difference distribution shows that the difference between Icare and GAT is 84% in 卤3mmHg range, and the difference value is 47% in 卤2mmHg range. The mean value of the difference between GAT and Icare is -2.6 mmHg, and the standard deviation is 4.17mmHg95%. The limit of (-10.8 ~ 5. 6) mmHg, was compared with the intraocular pressure measurements of GAT within the range of consistency limits. The absolute value of the difference is 10.8mmHg. The difference between IOPen and GAT was 49% in 卤3mmHg range, 34% in 卤2mmHg range and 16% in 卤2mmHg range. There was a linear correlation between 1mmHg and GAT. There was no linear correlation between rs=0.656,p0.01); IOPen and GAT (rs=0.122,p0.05). The average value of CCT was 539.90 卤31.85 渭 m.Icare.There was a positive correlation between GAT and CCT. The correlation coefficients were 0.382 (p0.01) and 0.342 (p0.01). IOPen had no linear correlation with CCT (rs=-0.073,P0.05). The difference between GAT and GAT was positively correlated with CCT (rs=0.180,P0.01). Conclusion there is a good correlation and consistency between the intraocular pressure measurements of GAT and that of the GAT. The IOP is easy to operate and needs no surface anesthesia, but the measured value is still affected by the central corneal thickness. Therefore, the effect of CCT on the results of Icare measurement should be considered in clinical practice, so that the true IOP can be more accurately reflected. The accuracy of intraocular pressure measured by IOPen was slightly poor.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R77
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