细菌生物膜厚度和面积对人耳听力的影响

发布时间：2018-10-25 06:13

【摘要】：依据临床健康志愿者右耳的CT扫描结果,将CT扫描数据数值化导入PATRAN软件进行人耳三维有限元模型的重建,并用NASTRAN软件对该模型进行频率响应分析。通过对正常人耳结构进行频率响应分析得出数据与实验数据吻合,验证了模型的正确性。结合临床中耳炎病症实际情况,研究细菌生物膜的成长阶段对人耳听力的影响。结果表明:在不同声压相同的频率段,细菌生物膜的厚度变化对人耳听力的影响是相同的。在相同声压不同频率段,细菌生物膜的厚度增加会引起镫骨振幅和速度降低,在较低频率段镫骨振幅和速度下降幅度较大,下降的最大值为1.64 d B;在较高频率段镫骨振幅和速度下降幅度较小,下降的最大值为1.04 d B。在不同声压作用下,在相同的频率段细菌生物膜的面积增加会引起镫骨振幅和速度降低。在100~1 000 Hz频率段镫骨振幅和速度的下降幅度较小,下降的最大值为0.18 d B。在1000~10 000 Hz频率段镫骨振幅和速度的下降幅度较大,下降的最大值为2.26 d B。细菌生物膜厚度或面积增加都会使人耳听力下降,厚度增加在低频时比高频时下降更多,而面积增加则刚好相反。
[Abstract]:According to the results of CT scan of right ear of healthy volunteers, the data of CT scan were imported into PATRAN software to reconstruct 3D finite element model of human ear, and the frequency response of the model was analyzed by NASTRAN software. Through the frequency response analysis of the normal ear structure, the data are in agreement with the experimental data, and the correctness of the model is verified. To study the effect of bacterial biofilm on human ear hearing in accordance with the actual situation of clinical otitis media. The results showed that the influence of the thickness of bacterial biofilm on human ear hearing was the same at the same frequency of different sound pressure. At the same sound pressure and different frequencies, the increase of the thickness of bacterial biofilm will cause the decrease of the amplitude and velocity of stapes, and the decrease of the amplitude and velocity of stapes at lower frequency. The maximum value of the decrease was 1.64 dB, and the amplitude and velocity of stapes decreased slightly at the higher frequency, and the maximum value of the decrease was 1.04 dB. Under different sound pressure, the increase of bacterial biofilm area at the same frequency would decrease the amplitude and velocity of stapes. The amplitudes and velocities of stapes were decreased slightly at the frequency of 100m 1 000 Hz, and the maximum value of the decrease was 0.18 dB. The amplitudes and velocities of stapes decreased greatly at 1000 ~ 10 000 Hz frequency, and the maximum value of the decrease was 2.26 dB. The increase of biofilm thickness or area of bacteria can decrease the hearing of human ear. The increase of biofilm thickness in low frequency is more than that in high frequency, but the increase in area is just the opposite.
【作者单位】：上海大学土木工程系;
【基金】：国家自然科学基金(11072143,11272200)
【分类号】：R764

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