血浆褪黑素与糖尿病视网膜病变的相关性研究

发布时间：2018-11-04 13:38

【摘要】：目的探讨血浆褪黑素(MLT)与DR的关系。方法选取T2DM患者82例和健康对照(NC)者41名,检测血浆MLT水平。将T2DM患者分为无DR(T2DM)组29例、非增殖型DR(NPDR)组30例和增殖型DR(PDR)组23例。各组分别采血检测日间、夜间血浆MLT水平。结果 PDR组夜间血浆MLT水平低于NC、T2DM、NPDR组[22.50(18.50,24.70)vs 32.70(29.30,36.70)、35.70(30.00,39.20)、32.30(28.50,35.90)pg/ml,P0.01],NC、T2DM和NPDR组夜间血浆MLT水平比较差异均无统计学意义(P0.05)。NC、T2DM、NPDR和PDR组日间血浆MLT水平比较差异无统计学意义[2.16(1.70,2.75)vs 1.76(1.46,2.12)vs 1.67(1.43,1.99)vs 1.50(0.93,1.60)pg/ml,P0.05]。单因素相关性分析结果显示,日间血浆MLT水平与病程呈负相关(r=-0.287,P=0.009),夜间血浆MLT水平与病程、胰岛素抵抗指数(HOMA-IR)呈负相关(r=-0.382、-0.238,P=0.001、0.009)。多元逐步回归分析结果显示,病程、FIns是日间血浆MLT水平的独立影响因素,病程是夜间血浆MLT水平的独立影响因素。结论 T2DM患者夜间血浆MLT水平降低,日间血浆MLT水平无明显变化,MLT可能在DR发病机制中发挥作用,且与DR严重程度相关。
[Abstract]:Objective to investigate the relationship between plasma melatonin (MLT) and DR. Methods Plasma MLT levels were measured in 82 patients with T2DM and 41 healthy controls with (NC). The patients with T2DM were divided into no DR (T2DM) group (29 cases), non proliferative DR (NPDR) group (30 cases) and proliferative DR (PDR) group (23 cases). Blood samples were collected from each group to detect the plasma MLT level in daytime and night. Results the level of plasma MLT in PDR group was lower than that in NC,T2DM,NPDR group [22.50 (18.50 卤24.70) vs 32.70 (29.30 ~ 36.70), 35.70 (30.0039.20), 32.30 (28.50 ~ 35.90) pg/ml,P0.01], NC,. There was no significant difference in plasma MLT levels between T2DM group and NPDR group (P0.05). NC,T2DM, There was no significant difference in plasma MLT levels between NPDR group and PDR group [2.16 (1.70 卤2.75) vs 1.76 (1.46n 2.12) vs 1.67 (1.43n1.99) vs 1.50 (0.931.60) pg/ml,P0.05]. Univariate correlation analysis showed that the plasma MLT level was negatively correlated with the course of disease (r-0.287), the night plasma MLT level was negatively correlated with the course of disease and the insulin resistance index (HOMA-IR) (r-0.382). -0.238m Pu 0.001n 0.009). Multiple stepwise regression analysis showed that the course of disease, FIns was an independent influence factor of daytime plasma MLT level, course of disease was an independent factor of night plasma MLT level. Conclusion the level of plasma MLT in patients with T2DM is lower than that of MLT in daytime. MLT may play an important role in the pathogenesis of DR, and it is related to the severity of DR.
【作者单位】：大连大学附属新华医院内分泌科;
【分类号】：R587.2;R774.1

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