明睛颗粒治疗湿性老年性黄斑变性的临床研究

发布时间：2018-11-11 00:47

【摘要】：目的观察明睛颗粒治疗湿性老年性黄斑变性临床疗效。方法本研究为临床配对研究,将120例(120眼)患者根据年龄、就诊时间、眼底特征进行1∶1配对研究,分为两组,每组60例(60眼),明睛颗粒组用明睛颗粒中药治疗,对照组用光动力疗法进行治疗,观察指标包括最佳矫正视力、眼底出血渗出面积、视网膜厚度、临床花费等。结果治疗3个月,两组患者视力及眼底疗效相当,差异均无统计学意义(视力疗效:Z=0.960,P=0.337;眼底疗效:Z=0.739,P=0.460);各组治疗前后眼部症状如眼底出血、渗出面积、矫正视力、视网膜厚度等情况比较:明睛颗粒组治疗后眼底出血渗出面积较治疗前减小,差异有统计学意义(t=2.055,P=0.047),视力、视网膜厚度比较差异均无统计学意义(视力:t=-0.712,P=0.479;视网膜厚度:t=-0.292,P=0.780);对照组治疗前后出血渗出面积、视力、视网膜厚度等改善不明显,差异均无统计学意义(均为P0.05);对脉络膜新生血管(CNV)的抑制方面,明睛颗粒治疗3个月,CNV活动性下降,但差异无统计学意义(Z=1.907,P=0.057),治疗6个月,CNV活动性明显减少,差异有统计学意义(Z=-4.846,P=0.000);两组医疗费用比较,明睛颗粒组为(3160.17±1309.34)元,对照组为(32 349.33±7897.94)元,差异有统计学意义(t=11.519,P=0.000)。随访3个月,两组均没有明显并发症发生。结论明睛颗粒和光动力疗法相比,均能够稳定并提高湿性老年性黄斑变性患者的视力,促进眼底出血渗出吸收,抑制新生血管的活动性,但临床医疗费用较低。因此,明睛颗粒也是治疗湿性老年性黄斑变性的一种不错的选择。
[Abstract]:Objective to observe the clinical effect of Mingjing granule on wettable senile macular degeneration. Methods in this study, 120 patients (120 eyes) were divided into two groups: 60 cases (60 eyes) in each group, and 60 cases (60 eyes) in each group. The patients in the control group were treated with photodynamic therapy, including best corrected visual acuity, hemorrhage area, retinal thickness, clinical cost and so on. Results after 3 months of treatment, the visual acuity and fundus effect of the two groups were similar, and there was no significant difference between the two groups. Comparison of ocular symptoms such as fundus hemorrhage, exudation area, corrected visual acuity and retinal thickness before and after treatment. There was no significant difference in visual acuity and retinal thickness (visual acuity: t0. 712) and retinal thickness (P < 0. 479). Retinal thickness: t0. 292 and Pu 0. 780); in the control group, there was no significant improvement in hemorrhage exudation area, visual acuity and retinal thickness before and after treatment, but there was no significant difference between the two groups (P0.05). For the inhibition of (CNV) in choroidal neovascularization, the activity of CNV decreased after 3 months of treatment with Mingjing granule, but the difference was not statistically significant (ZH 1.907 Pn0. 057). After 6 months of treatment, the activity of CNV decreased significantly. The difference was statistically significant (ZAL-4.846 P0. 000). The medical expenses of the two groups were (3160.17 卤1309.34) yuan in the Mingjing granule group and (32 349.33 卤7897.94) yuan in the control group. The difference was statistically significant (t = 11.519). After 3 months follow-up, no significant complications occurred in both groups. Conclusion compared with photodynamic therapy, Mingjing granule can stabilize and improve the visual acuity of patients with wettable age-related macular degeneration, promote the absorption of fundus hemorrhage and inhibit the activity of neovascularization, but the cost of clinical treatment is relatively low. Therefore, Mingjing granule is also a good choice for the treatment of wet age-related macular degeneration.
【作者单位】：中国中医科学院眼科医院;北京协和医院眼科;北京医院眼科;
【基金】：首都医学科技发展基金(编号:2005-SF-Ⅱ-010) 十一五国家科技支撑项目(编号:2006BAI04A18)~~
【分类号】：R774.5

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