慢性扁桃体炎与早期肾脏损害的相关性研究

发布时间：2018-11-24 10:22

【摘要】：目的探讨慢性扁桃体炎患者是否有存在尿微量白蛋白含量异常，并发早期肾脏损害；分析尿微量白蛋白作为判断慢性扁桃体炎早期肾脏损害的诊断指标是否可靠；扁桃体切除术是否能够降低尿微量白蛋白含量，成为防止慢性扁桃体炎并发早期肾脏损害的有效方法之一。方法选取2012年3月～2013年2月青海大学附属医院耳鼻喉科慢性扁桃体炎患者84例，男性33例，女性51例，，年龄7～55岁。按病程分为3组,甲组：病程12月以上；乙组:病程36月以上；丙组；病程60月以上；在免疫检验室收集12例非慢性扁桃体炎标本正常者为对照组，男性7例，女性5例，年龄7～55岁。采用速率散射比浊法测定手术治疗前、后尿微量白蛋白含量。对所采集数据进行统计学分析。结果1.甲组术前尿微量白蛋白含量与对照组尿微量白蛋白含量比较，p0.05，无统计学意义。其余各组术前尿微量白蛋白含量两两多重比较均为P＜0.05，差异有统计学意义。 2.甲组、乙组、丙组手术前后尿微量白蛋白含量比较均为P＜0.05，差异有统计学意义。 3.慢性扁桃体炎患者尿微量白蛋白含量为非正态性分布，慢性扁桃体炎患者病程与尿微量白蛋白含量秩相关分析rs=0.659，P0.001,说明慢性扁桃体炎患者病程与尿微量白蛋白含量有相关性。结论1、病程60月以上的慢性扁桃体炎患者尿微量白蛋白排泄量超出正常范围,可并发早期肾脏损害； 2、尿微量白蛋白作为判断慢性扁桃体炎早期肾脏损害的诊断指标有一定临床指导价值，且随着病程进展其敏感性逐渐增加； 3、慢性扁桃体炎患者在扁桃体切除术术后尿微量白蛋白含量有明显下降，扁桃体切除术对防治早期肾脏损害有明显的疗效。
[Abstract]:Objective to investigate the presence of urinary microalbumin in patients with chronic tonsillitis complicated with early renal damage, and to analyze the reliability of urinary microalbumin as a diagnostic index for early renal damage in chronic tonsillitis. Tonsillectomy is one of the effective methods to prevent early renal damage in chronic tonsillitis. Methods from March 2012 to February 2013, 84 patients with chronic tonsillitis in the department of otolaryngology, affiliated hospital of Qinghai University, including 33 males and 51 females, aged 755 years, were selected. According to the course of disease, group A: course of disease more than 12 months, group B: course of disease more than 36 months, group C, course of disease more than 60 months; 12 normal specimens of non-chronic tonsillitis were collected in the immunological laboratory as control group. There were 7 males and 5 females aged 755 years. Urinary microalbuminuria was determined by rate scattering turbidimetry before and after operation. The collected data were analyzed statistically. Result 1. There was no significant difference between group A and control group (P 0.05). There was significant difference between the other groups (P < 0.05). 2. The levels of urinary microalbumin in group A, group B and group C were significantly higher than those in group A, B and C before and after operation (P < 0.05). 3. The content of urinary microalbumin in patients with chronic tonsillitis was non-normal distribution. The rank correlation analysis of rs=0.659,P0.001, between the course of disease and the content of urinary microalbumin in patients with chronic tonsillitis The results showed that the course of chronic tonsillitis was correlated with the content of urinary albumin in patients with chronic tonsillitis. Conclusion 1. The urinary microalbumin excretion of chronic tonsillitis patients whose course of disease is over 60 months exceeds the normal range and can be complicated with early renal damage. 2. Urinary microalbumin as a diagnostic index for early renal damage in chronic tonsillitis has a certain clinical guiding value, and its sensitivity increases with the progression of the disease. 3. After tonsillectomy, urinary microalbuminuria decreased significantly in patients with chronic tonsillitis, and tonsillectomy was effective in the prevention and treatment of early renal damage.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R766.18

【参考文献】