喉癌中HSP-70、Ki-67和CA19-9的表达及其临床意义的研究
发布时间：2018-12-08 10:32
【摘要】：喉癌是耳鼻咽喉科常见的恶性肿瘤,近年来发病率有明显的增高趋势。随着分子生物学技术等研究技术发展,肿瘤研究的不断深人,已经有越来越多的耳鼻咽喉科研究者将目光聚焦于喉癌的研究。本研究即通过免疫组织化学方法对人66例喉癌组织及12例癌旁组织进行了HSP-70、Ki-67、CA19-9三种肿瘤生物学标记物检测,探讨三种蛋白表达在喉癌中的表达及其意义。结果表明在喉癌组织中,HSP-70、Ki-67、CA19-9的表达明显高于12例癌旁组织的表达,有统计学显著性差异(P0.05)。HSP-70、Ki-67、CA19-9阳性表达率与喉癌患者的年龄、性别、临床分型无关。HSP-70阳性表达率与肿瘤分期、淋巴结转移有关(P0.05)。ki-67的表达与肿瘤分期有关(P0.05)。CA19-9的表达与肿瘤分期、分化程度、淋巴结转移有关(P0.05)。结果提示HSP-70、Ki-67和CA19-9作为喉癌的生物学标志物在喉癌的发生、发展、恶变中可能具有重要作用,可用于喉癌恶性程度的评价。
[Abstract]:Laryngeal carcinoma is a common malignant tumor in otorhinolaryngology. With the development of molecular biology and other research techniques, more and more researchers in otorhinolaryngology have focused on the study of laryngeal carcinoma. In this study, we detected the expression of HSP-70,Ki-67,CA19-9 in 66 human laryngeal carcinoma tissues and 12 paracancerous tissues by immunohistochemical method, and discussed the expression and significance of three proteins in laryngeal carcinoma. The results showed that the expression of HSP-70,Ki-67,CA19-9 in laryngeal carcinoma tissues was significantly higher than that in 12 paracancerous tissues (P0.05). The positive expression rate of CA19-9 was not related to the age, sex and clinical type of laryngeal cancer patients. The positive expression rate of HSP-70 was correlated with the tumor stage. The expression of ki-67 was related to tumor stage (P0.05). The expression of CA19-9 was related to tumor stage, differentiation degree and lymph node metastasis (P0.05). The results suggest that HSP-70,Ki-67 and CA19-9 as biomarkers of laryngeal carcinoma may play an important role in the occurrence, development and malignancy of laryngeal carcinoma, and can be used to evaluate the malignant degree of laryngeal carcinoma.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R739.65
本文编号：2368200
[Abstract]:Laryngeal carcinoma is a common malignant tumor in otorhinolaryngology. With the development of molecular biology and other research techniques, more and more researchers in otorhinolaryngology have focused on the study of laryngeal carcinoma. In this study, we detected the expression of HSP-70,Ki-67,CA19-9 in 66 human laryngeal carcinoma tissues and 12 paracancerous tissues by immunohistochemical method, and discussed the expression and significance of three proteins in laryngeal carcinoma. The results showed that the expression of HSP-70,Ki-67,CA19-9 in laryngeal carcinoma tissues was significantly higher than that in 12 paracancerous tissues (P0.05). The positive expression rate of CA19-9 was not related to the age, sex and clinical type of laryngeal cancer patients. The positive expression rate of HSP-70 was correlated with the tumor stage. The expression of ki-67 was related to tumor stage (P0.05). The expression of CA19-9 was related to tumor stage, differentiation degree and lymph node metastasis (P0.05). The results suggest that HSP-70,Ki-67 and CA19-9 as biomarkers of laryngeal carcinoma may play an important role in the occurrence, development and malignancy of laryngeal carcinoma, and can be used to evaluate the malignant degree of laryngeal carcinoma.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R739.65
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