老年眼睑基底细胞癌患者癌组织中空泡膜蛋白1、磷酸酶及张力蛋白同源蛋白和抗转移蛋白23的表达及意义

发布时间：2018-12-17 14:56

【摘要】：目的检测老年眼睑基底细胞癌患者癌组织空泡膜蛋白(VMP)1、磷酸酶及张力蛋白同源蛋白(PTEN)和抗转移蛋白(NM)23的表达及相关性。方法 97例老年基底细胞癌患者术后存档的蜡块组织及临床资料为观察组,上述肿瘤组织周边切缘为正常鳞状上皮组织患者60例为对照组,采用免疫组织化学染色方法检测VMP1、PTEN和NM23表达。结果观察组VMP1、PTEN和NM23表达阳性率明显低于对照组,观察组VMP1、PTEN和NM23表达阳性率与肿瘤最大径、是否侵犯皮肤外结构、转移及Ki67表达密切相关。观察组VMP1、PTEN和NM23表达具有正相关性。结论老年眼睑基底细胞癌患者癌组织中VMP1、PTEN和NM23蛋白表达均下调,三者具有协同正向作用,共同促进肿瘤的发生和进展。
[Abstract]:Objective to detect the expression of vacuolar membrane protein (VMP) _ 1), phosphatase and tension protein homologue (PTEN) and anti-metastasis protein (NM) _ 23) in carcinoma of eyelid basal cell carcinoma (BCC) in elderly patients. Methods the paraffin tissue and clinical data of 97 elderly patients with basal cell carcinoma were observed as observation group and 60 patients with normal squamous epithelium as control group. Immunohistochemical staining was used to detect VMP1,. PTEN and NM23 expression. Results the positive rate of VMP1,PTEN and NM23 expression in the observation group was significantly lower than that in the control group. The positive rate of VMP1,PTEN and NM23 expression in the observation group was closely related to the maximum diameter of the tumor, invasion of the outer structure of the skin, metastasis and Ki67 expression. There was a positive correlation between the expression of VMP1,PTEN and NM23 in the observation group. Conclusion the expression of VMP1,PTEN and NM23 protein are down-regulated in patients with basal cell carcinoma of eyelid. These three proteins have synergistic positive effect and promote the occurrence and progression of the tumor.
【作者单位】：青海大学附属医院眼科;
【分类号】：R739.7

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