阻塞性睡眠呼吸暂停低通气综合征与动脉粥样硬化相关性的临床研究
发布时间：2018-12-17 20:51
【摘要】：第一部分OSAHS患者血尿酸水平与颈动脉粥样硬化的关系 目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者病情与血浆尿酸(UA)水平及颈动脉粥样硬化的关系。方法选取经多导睡眠监测仪(PSG)诊断的OSAHS患者64例,根据呼吸暂停低通气指数(AHI)分为轻度亚组20例,中度亚组22例,重度亚组22例。应用彩色多普勒超声检测颈动脉内-中膜厚度(IMT),测定血UA的水平,并与20名正常对照组比较。结果轻度、中度、重度OSAHS亚组患者的血UA水平均显著高于正常对照组,且OSAHS各亚组间差异有统计学意义(均P0.01);OSAHS重度亚组颈动脉IMT较正常对照组和OSAHS轻度亚组明显增厚(均P0.01);血UA水平与颈动脉IMT、AHI呈正相关(r=0.746, r=0.798),与夜间最低血氧饱和度(SpO2)负相关(r =-0.754)(均P0.01)。结论OSAHS患者颈动脉IMT增厚,血UA水平升高,并可反映OSAHS严重程度。 第二部分OSAHS患者颈动脉及下肢动脉硬化斑块的临床研究 目的探讨中青年OSAHS患者与颈动脉和下肢动脉粥样硬化斑块之间的关系。方法应用PSG诊断的110例OSAHS患者分成轻度组(36例)、中度组(38例)、重度组(36例),另设36名健康体检者作为对照组,所有入选者行颈动脉和下肢动脉彩色多普勒超声检测。结果OSAHS患者颈动脉和(或)下肢动脉粥样硬化斑块检出率明显高于对照组(P0.05),且随着程度加重斑块的发生率有增加的趋势。结论OSAHS是动脉粥样硬化的独立影响因素。
[Abstract]:Part I the relationship between serum uric acid level and carotid atherosclerosis in patients with OSAHS objective to investigate the relationship between serum uric acid (UA) level and carotid atherosclerosis in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Sixty-four patients with OSAHS diagnosed by polysomnography (PSG) were divided into mild subgroup (n = 20), moderate subgroup (n = 22) and severe subgroup (n = 22) according to apnea hypopnea index (AHI). The level of blood UA was measured by color Doppler ultrasound (CDFI) in carotid intima-media thickness (IMT), and compared with that in 20 normal controls. Results the serum UA levels in mild, moderate and severe OSAHS subgroups were significantly higher than those in normal controls, and there were significant differences among OSAHS subgroups (P0.01). The carotid IMT in the severe subgroup of OSAHS was significantly thicker than that in the normal control group and the mild subgroup of OSAHS (P0.01). The serum UA level was positively correlated with carotid IMT,AHI (r = 0.746, r = 0.798), and negatively correlated with nocturnal minimum oxygen saturation (SpO2) (r =-0.754). Conclusion carotid IMT is thickened and serum UA level is increased in OSAHS patients, which can reflect the severity of OSAHS. The second part: clinical study of carotid and lower extremity arteriosclerotic plaques in patients with OSAHS objective to investigate the relationship between carotid artery and lower extremity atherosclerotic plaques in young and middle-aged patients with OSAHS. Methods 110 patients with OSAHS diagnosed by PSG were divided into three groups: mild group (36 cases), moderate group (38 cases), severe group (36 cases). The carotid and lower extremity arteries were detected by color Doppler ultrasound. Results the detection rate of carotid and / or lower extremity atherosclerotic plaques in OSAHS patients was significantly higher than that in the control group (P0.05), and the incidence of plaque increased with the severity of Atherosclerotic plaque. Conclusion OSAHS is an independent factor of atherosclerosis.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766
本文编号：2384781
[Abstract]:Part I the relationship between serum uric acid level and carotid atherosclerosis in patients with OSAHS objective to investigate the relationship between serum uric acid (UA) level and carotid atherosclerosis in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Sixty-four patients with OSAHS diagnosed by polysomnography (PSG) were divided into mild subgroup (n = 20), moderate subgroup (n = 22) and severe subgroup (n = 22) according to apnea hypopnea index (AHI). The level of blood UA was measured by color Doppler ultrasound (CDFI) in carotid intima-media thickness (IMT), and compared with that in 20 normal controls. Results the serum UA levels in mild, moderate and severe OSAHS subgroups were significantly higher than those in normal controls, and there were significant differences among OSAHS subgroups (P0.01). The carotid IMT in the severe subgroup of OSAHS was significantly thicker than that in the normal control group and the mild subgroup of OSAHS (P0.01). The serum UA level was positively correlated with carotid IMT,AHI (r = 0.746, r = 0.798), and negatively correlated with nocturnal minimum oxygen saturation (SpO2) (r =-0.754). Conclusion carotid IMT is thickened and serum UA level is increased in OSAHS patients, which can reflect the severity of OSAHS. The second part: clinical study of carotid and lower extremity arteriosclerotic plaques in patients with OSAHS objective to investigate the relationship between carotid artery and lower extremity atherosclerotic plaques in young and middle-aged patients with OSAHS. Methods 110 patients with OSAHS diagnosed by PSG were divided into three groups: mild group (36 cases), moderate group (38 cases), severe group (36 cases). The carotid and lower extremity arteries were detected by color Doppler ultrasound. Results the detection rate of carotid and / or lower extremity atherosclerotic plaques in OSAHS patients was significantly higher than that in the control group (P0.05), and the incidence of plaque increased with the severity of Atherosclerotic plaque. Conclusion OSAHS is an independent factor of atherosclerosis.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766
【参考文献】
相关期刊论文 前2条
1 张红;张锦;;OSAHS及高血压患者血清尿酸水平的临床研究[J];宁夏医学杂志;2007年07期
2 中华医学会呼吸病学分会睡眠呼吸疾病学组;阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J];中华结核和呼吸杂志;2002年04期
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