乙酰肝素酶、蛋白激酶CK2β与缺氧诱导因子-1α在鼻咽癌组织中的表达及其相关性研究

发布时间：2018-12-21 07:26

【摘要】：目的:检测乙酰肝素酶(HPA)、蛋白激酶CK2β(CK2β)、缺氧诱导因子-1α(HIF-1α)在鼻咽癌(NPC)组织中的表达及其与临床特征之间的关系;并分析三者在NPC组织中表达的相关性。方法:采用免疫组织化学染色技术Super-Vision法检测49例NPC组织标本及15例慢性鼻咽炎(CNT)组织标本中HPA、CK2β及HIF-1α的表达水平。结果:HPA、CK2β与HIF-1α在NPC组织中的表达水平均高于CNT组织中的表达,差异均有统计学意义(P0.05);HPA、CK2β与HIF-1α的表达与NPC临床分期、治疗后有无复发或转移相关(P0.05),与患者的性别无关(P0.05);HIF-1α的表达水平与NPC患者的年龄密切相关(P0.01),而HPA、CK2β的表达水平则与NPC患者的年龄无关(P0.05);HPA、CK2β与HIF-1α任意两者间在NPC组织中的表达均呈正相关性(P0.05)。结论:HPA、CK2β和HIF-1α参与了NPC的发生和发展、浸润及转移;在NPC的发生发展过程中,HPA、CK2β和HIF-1α之间可能存在协同作用。
[Abstract]:Objective: to investigate the expression of heparanase (HPA), protein kinase CK2 尾 (CK2 尾) and hypoxia inducible factor-1 伪 (HIF-1 伪) in (NPC) of nasopharyngeal carcinoma (NPC). The correlation between the expression of the three proteins in NPC tissues was analyzed. Methods: the expression of HPA,CK2 尾 and HIF-1 伪 in 49 cases of NPC and 15 cases of (CNT) in chronic nasopharyngitis were detected by immunohistochemical staining Super-Vision method. Results: the expression levels of HPA,CK2 尾 and HIF-1 伪 in NPC were significantly higher than those in CNT (P0.05). The expression of HPA,CK2 尾 and HIF-1 伪 was related to the clinical stage of NPC and the recurrence or metastasis after treatment (P0.05), but not to the sex of the patients (P0.05). The expression level of HIF-1 伪 was closely related to the age of NPC patients (P0.01), while the expression level of HPA,CK2 尾 was not related to the age of NPC patients (P0.05). There was a positive correlation between the expression of HPA,CK2 尾 and HIF-1 伪 in NPC tissues (P0.05). Conclusion: HPA,CK2 尾 and HIF-1 伪 are involved in the occurrence, development, infiltration and metastasis of NPC, and there may be a synergistic effect between HPA,CK2 尾 and HIF-1 伪 during the development of NPC.
【作者单位】：汕头市中心医院耳鼻咽喉头颈外科;茂名市人民医院耳鼻咽喉科;
【基金】：汕头市重点科技计划项目(No:汕府科2010-63-27)
【分类号】：R739.63

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