中耳胆脂瘤上皮组织中IL-6和P-STAT3的表达及意义
发布时间：2018-12-29 10:15
【摘要】：目的：研究中耳胆脂瘤上皮组织中IL-6和P-STAT3的表达及其相关性,探讨IL-6和P-STAT3在中耳胆脂瘤发生和发展中的作用。 方法：采用免疫组织化学SP法(SP immunohistochemical method)检测25例成人中耳胆脂瘤上皮组织中IL-6和P-STAT3蛋白的表达情况,另取其中15例患者的正常外耳道皮肤组织作为对照。应用SPSS15.0软件进行统计学分析。 结果：25例中耳胆脂瘤上皮组织中,IL-6蛋白表达阳性18例(72.00%), P-STAT3蛋白表达阳性16例(64.00%)。15例对照组标本中IL-6和P-STAT3蛋白阳性表达分别为3例(20.00%)和4例(26.67%),两组差异具有统计学意义(P0.05)；中耳胆脂瘤组IL-6和P-STAT3的表达具有正相关性(r=0.46,P0.05)。 结论：IL-6、P-STAT3在中耳胆脂瘤上皮组织中呈异常高表达,提示IL-6蛋白和P-STAT3蛋白过度表达可能与胆脂瘤上皮的高度增殖状态密切相关,在中耳胆脂瘤的发生与发展中发挥着一定作用。IL-6蛋白和P-STAT3蛋白表达呈正相关,提示IL-6-STAT3信号传导通路在中耳胆脂瘤上皮的过度增殖机制中起到重要作用。
[Abstract]:Objective: to investigate the expression of IL-6 and P-STAT3 in middle ear cholesteatoma and their correlation, and to explore the role of IL-6 and P-STAT3 in the pathogenesis and development of middle ear cholesteatoma. Methods: the expression of IL-6 and P-STAT3 protein in 25 cases of adult middle ear cholesteatoma was detected by immunohistochemical SP (SP immunohistochemical method) method, and 15 cases of normal external auditory canal skin tissue were used as control. SPSS15.0 software was used for statistical analysis. Results: in 25 cases of middle ear cholesteatoma, 18 cases (72.00%) were positive for IL-6 protein expression. There were 16 cases (64.00%) positive expression of P-STAT3 protein, 3 cases (20.00%) of IL-6 and 4 cases (26.67%) of P-STAT3 protein in 15 cases of control group, the difference was statistically significant (P0.05). There was a positive correlation between the expression of IL-6 and P-STAT3 in middle ear cholesteatoma group (P 0.05). Conclusion: the overexpression of IL-6,P-STAT3 in the epithelium of middle ear cholesteatoma suggests that the overexpression of IL-6 protein and P-STAT3 protein may be closely related to the high proliferation of cholesteatoma epithelium. The expression of IL-6 protein and P-STAT3 protein were positively correlated, suggesting that IL-6-STAT3 signal transduction pathway plays an important role in the mechanism of excessive proliferation of middle ear cholesteatoma epithelium.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R764
本文编号：2394708
[Abstract]:Objective: to investigate the expression of IL-6 and P-STAT3 in middle ear cholesteatoma and their correlation, and to explore the role of IL-6 and P-STAT3 in the pathogenesis and development of middle ear cholesteatoma. Methods: the expression of IL-6 and P-STAT3 protein in 25 cases of adult middle ear cholesteatoma was detected by immunohistochemical SP (SP immunohistochemical method) method, and 15 cases of normal external auditory canal skin tissue were used as control. SPSS15.0 software was used for statistical analysis. Results: in 25 cases of middle ear cholesteatoma, 18 cases (72.00%) were positive for IL-6 protein expression. There were 16 cases (64.00%) positive expression of P-STAT3 protein, 3 cases (20.00%) of IL-6 and 4 cases (26.67%) of P-STAT3 protein in 15 cases of control group, the difference was statistically significant (P0.05). There was a positive correlation between the expression of IL-6 and P-STAT3 in middle ear cholesteatoma group (P 0.05). Conclusion: the overexpression of IL-6,P-STAT3 in the epithelium of middle ear cholesteatoma suggests that the overexpression of IL-6 protein and P-STAT3 protein may be closely related to the high proliferation of cholesteatoma epithelium. The expression of IL-6 protein and P-STAT3 protein were positively correlated, suggesting that IL-6-STAT3 signal transduction pathway plays an important role in the mechanism of excessive proliferation of middle ear cholesteatoma epithelium.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R764
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