鼻咽癌高发区人群初筛后1年随访结果分析

发布时间：2019-01-04 10:54

【摘要】：目的:观察高发区初筛1年后鼻咽癌一级亲属、一般人群血清EB病毒抗体的动态变化及鼻咽癌检出情况。方法:收集参加2009年8月至2010年7月广东省中山市小榄镇鼻咽癌初筛和2011年8月随访的人群EB病毒血清学资料与鼻咽癌检出情况,比较鼻咽癌一级亲属和一般人群中EB病毒抗体变化及鼻咽癌检出情况。结果:亲属组NA1/IgA转阴率高于对照组(χ2=20.28,P0.001),且男、女性亲属组分别高于男、女性对照组(χ2=22.59,P0.001;χ2=4.03,P0.05);亲属组NA1/IgA转阳率低于对照组(χ2=7.79,P=0.005),男性亲属组高于男性对照组(χ2=9.46,P=0.002),而女性亲属组与女性对照组比较差异无统计学意义(χ2=0.74,P0.05)。亲属组VCA/IgA转阴率高于对照组(χ2=1.90,P=0.001),男性亲属组高于男性对照组(χ2=7.50,P=0.005),而女性亲属组与女性对照组比较差异无统计学意义(χ2未见表达,P0.05)。亲属组VCA/IgA转阳率高于对照组,但差异无统计学意义(χ2=0.10,P0.05)。亲属组未检出新发鼻咽癌,对照组检出10例,对照组鼻咽癌检出率显著高于亲属组,但差异无统计学意义(χ2=1.05,P0.05)。结论:EB病毒的变化与遗传因素可能不存在密切联系;初筛后鼻咽癌一级亲属鼻咽癌检出并不高于一般人群,可能无需采取选择性随访原则。
[Abstract]:Objective: to observe the dynamic changes of serum EB virus antibody and the detection of nasopharyngeal carcinoma (NPC) in primary relatives of NPC and general population after 1 year screening in high incidence area. Methods: the serological data of EB virus and the detection of nasopharyngeal carcinoma were collected from the primary screening of nasopharyngeal carcinoma in Xiaolan Town, Zhongshan City, Guangdong Province from August 2009 to July 2010 and followed up in August 2011. To compare the changes of EB antibody and the detection of nasopharyngeal carcinoma in the first degree relatives of NPC and the general population. Results: the negative conversion rate of NA1/IgA in relative group was higher than that in control group (蠂 2 + 20.28 P 0.001), and that in male group and female group was higher than that in male group and female group (蠂 2 + 22.59% P 0.001; 蠂 2 + 4.03 P 0.05). The positive rate of NA1/IgA in the relative group was lower than that in the control group (蠂 ~ 2 / 7. 79% P ~ (0.005), and that in the male relatives group was higher than that in the male control group (蠂 ~ (2) 9.46), but there was no significant difference between the female relatives group and the female control group (蠂 ~ (2) 0.74). P0.05). The negative conversion rate of VCA/IgA in the relatives group was higher than that in the control group (蠂 ~ (2) 1.90), and that in the male relative group was higher than that in the male control group (蠂 ~ (2) 7.50), but there was no significant difference between the female relatives group and the female control group (蠂 ~ (2). P0.05). The positive rate of VCA/IgA in relatives group was higher than that in control group, but there was no significant difference (蠂 2 0. 10 P 0.05). The positive rate of nasopharyngeal carcinoma in the control group was significantly higher than that in the relative group, but the difference was not statistically significant (蠂 2 + 1.05 P 0.05). Conclusion: there may be no close relationship between the changes of EB virus and genetic factors, and the detection of nasopharyngeal carcinoma in primary relatives of nasopharyngeal carcinoma after primary screening is not higher than that of the general population, so the selective follow-up may not be necessary.
【作者单位】：中山大学人民医院肿瘤研究所;中山大学肿瘤防治中心华南肿瘤学国家重点实验室;
【基金】：国家“十一五”科技支撑计划项目(编号:2006BAI02A11) 中央补助地方公共卫生专项资金癌症早诊早治项目资助~~
【分类号】：R739.63

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