术后放疗对于鼻腔鼻窦恶性黑色素瘤疗效的Meta分析
发布时间：2019-01-04 16:32
【摘要】：背景：鼻腔鼻窦恶性黑色素瘤是一种少见的恶性肿瘤,其预后差,目前临床上常用的治疗方案未能达到有效的控制。目的：通过与单纯手术治疗的对比,对术后放疗在鼻腔鼻窦恶性黑色素瘤中的临床应用价值进行系统评价。方法：检索PubMed、Web of science、Ovid3个数据库截止至2013年12月的文献,从中进行筛选,并对纳入结果进行Meta分析。结局评价指标为术后总体生存率、无瘤生存率和肿瘤局部控制率。结果：共纳入19篇研究,涉及654例病例,其中术后放疗组313例,单纯手术组341例。术后放疗组患者的1年、3年、5年总体生存率较单纯手术组无显著提高,其RR值和95%CI分别为1.03(0.92,1.14),1.05(0.88,1.27)和1.29(0.96,1.72)。术后无瘤生存率和肿瘤局部控制率也无显著优势,1年、3年、5年无瘤生存率的RR值和95%CI分别为0.77(0.50,1.18),1.17(0.66,2.07)和0.80(0.46,1.39)；1年、3年、5年局部控制率的RR值和95%CI为1.07(0.87,1.32),1.11(0.80,1.56)和0.86(0.52,1.43；P=0.5)。结论：与单纯手术治疗相比,术后放疗对鼻腔鼻窦恶性黑色素瘤患者的总体生存率、无瘤生存率和肿瘤局部控制率均无显著改善。
[Abstract]:Background: malignant melanoma of nasal cavity and paranasal sinus is a rare malignant tumor with poor prognosis. Objective: to evaluate the clinical value of postoperative radiotherapy in malignant melanoma of nasal cavity and paranasal sinus. Methods: the literatures of PubMed,Web of science,Ovid3 database as of December 2013 were searched and screened, and the included results were analyzed by Meta. The outcome criteria were overall survival rate, tumor-free survival rate and tumor local control rate. Results: a total of 19 studies involved 654 cases, including 313 cases in postoperative radiotherapy group and 341 cases in simple operation group. The 1 year, 3 year and 5 year overall survival rate of postoperative radiotherapy group was not significantly higher than that of simple operation group. The RR value and 95%CI were 1. 03 (0. 92 卤1. 14), 1. 05 (0. 88 卤1. 27) and 1. 29 (0. 966 / 1. 72), respectively. There was no significant difference in tumor free survival rate and tumor local control rate. The RR and 95%CI of 1 year, 3 year and 5 year free survival rates were 0. 77 (0. 50 卤1. 18), respectively. 1.17 (0.66U 2.07) and 0.80 (0.46L 1.39); The RR value and 95%CI of local control rate of 1 year, 3 years and 5 years were 1. 07 (0. 87 ~ 1. 32), 1. 11 (0. 80 ~ 1. 56) and 0. 86 (0. 52 ~ 1. 43 P0. 5) respectively. Conclusion: the overall survival rate, tumor-free survival rate and tumor local control rate of patients with malignant melanoma of nasal cavity and paranasal sinus treated by postoperative radiotherapy were not significantly improved compared with surgical treatment alone.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R739.62
本文编号：2400526
[Abstract]:Background: malignant melanoma of nasal cavity and paranasal sinus is a rare malignant tumor with poor prognosis. Objective: to evaluate the clinical value of postoperative radiotherapy in malignant melanoma of nasal cavity and paranasal sinus. Methods: the literatures of PubMed,Web of science,Ovid3 database as of December 2013 were searched and screened, and the included results were analyzed by Meta. The outcome criteria were overall survival rate, tumor-free survival rate and tumor local control rate. Results: a total of 19 studies involved 654 cases, including 313 cases in postoperative radiotherapy group and 341 cases in simple operation group. The 1 year, 3 year and 5 year overall survival rate of postoperative radiotherapy group was not significantly higher than that of simple operation group. The RR value and 95%CI were 1. 03 (0. 92 卤1. 14), 1. 05 (0. 88 卤1. 27) and 1. 29 (0. 966 / 1. 72), respectively. There was no significant difference in tumor free survival rate and tumor local control rate. The RR and 95%CI of 1 year, 3 year and 5 year free survival rates were 0. 77 (0. 50 卤1. 18), respectively. 1.17 (0.66U 2.07) and 0.80 (0.46L 1.39); The RR value and 95%CI of local control rate of 1 year, 3 years and 5 years were 1. 07 (0. 87 ~ 1. 32), 1. 11 (0. 80 ~ 1. 56) and 0. 86 (0. 52 ~ 1. 43 P0. 5) respectively. Conclusion: the overall survival rate, tumor-free survival rate and tumor local control rate of patients with malignant melanoma of nasal cavity and paranasal sinus treated by postoperative radiotherapy were not significantly improved compared with surgical treatment alone.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R739.62
【参考文献】
相关期刊论文 前1条
1 汪庆余;雷瑛;邬黎青;冯琼;;恶性黑色素瘤临床病理诊断分析[J];实验与检验医学;2009年05期
，本文编号：2400526
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