变应性鼻炎患者主客观指标相关性研究

发布时间：2019-01-04 22:34

【摘要】：目的:分析成人变应性鼻炎患者的血清变应原特异性IgE(Serum allergen specific IgE,sIgE)、皮肤点刺试验(Skin prick test,SPT)及外周血嗜酸性粒细胞(Peripheral eosinophilic,Eos)计数与鼻部症状视觉模拟量表评分(Visual analogue scale,VAS)的相关性。方法:2009年9月~2011年5月我科就诊的变应性鼻炎患者66人,男31人,女35人,年龄20~76岁,平均(34.17±13.51)岁。通过病史、典型试验量表对喷嚏,清涕,鼻堵,鼻痒评分,分别分析血清sIgE、SPT与VAS评分和外周血嗜酸性粒细胞计数之间的相关性。结果:血清sIgE和皮肤点刺试验显著正相关(r=0.532,P0.01);血清sIgE、SPT与鼻部症状VAS总分及外周血嗜酸性粒细胞计数均无明显相关性。结论:血清sIgE和皮肤点刺试验对诊断变应性鼻炎都具有显著意义,皮肤点刺试验反应、血清特异性IgE水平和外周血嗜酸细胞计数不能正确反应变应性鼻炎患者的临床症状和生活质量状况。
[Abstract]:Objective: to analyze serum allergen specific IgE (Serum allergen specific IgE,sIgE, skin prick test (Skin prick test,SPT) and peripheral eosinophil (Peripheral eosinophilic, in adult allergic rhinitis patients. The correlation between Eos count and visual analogue scale score (Visual analogue scale,VAS) of nasal symptoms. Methods: from September 2009 to May 2011, 66 patients with allergic rhinitis, 31 males and 35 females, with an average age of (34.17 卤13.51), were enrolled in our department. The correlation between serum sIgE,SPT and VAS score and eosinophil count in peripheral blood was analyzed by means of history, canonical test scale, nasal obstruction score, nasal itching score. Results: there was a significant positive correlation between serum sIgE and skin prick test (r = 0.532P 0.01), but no significant correlation between serum sIgE,SPT and total VAS score of nasal symptoms and eosinophil count in peripheral blood. Conclusion: serum sIgE and skin prick test are significant in the diagnosis of allergic rhinitis. The clinical symptoms and quality of life of patients with allergic rhinitis could not be correctly responded to by serum specific IgE level and peripheral blood eosinophil count.
【作者单位】：北京大学人民医院耳鼻喉科;
【基金】：北京市科技计划课题(No.Z090507017709033)
【分类号】：R765.21

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