系统性红斑狼疮视网膜病变的临床特点分析

发布时间：2019-01-17 11:44

【摘要】：目的总结临床系统性红斑狼疮(SLE)合并视网膜病变患者的临床特点,以提升对该病症的认识。方法回顾性分析30例SLE合并视网膜病变患者的临床资料。结果 30例患者均伴有不同程度的身体其他器官受累情况,以累及皮肤者比例最高,占70.00%,其次是肾脏病变与中枢神经系统损伤,分别占46.67%、43.33%;所有患者均为狼疮活动期,并以中度活动者最多,占70.00%,且经相关实验室检查,所有患者的抗核抗体(ANA)均显示为阳性,且其中,18例(60.00%)患者的抗双链DNA显示为阳性,10例(33.33%)患者显示为抗心磷脂抗体阳性;30例患者共累及44只眼,28例患者均伴有不同程度的视力降低,且有7例患者因视力降低来院就诊,22只眼视力在0.1~0.5间,14只眼视力在0.5以上,其余8只眼视力均在0.1以下;而关于患者眼部病变,30只眼表现为以视网膜棉绒斑、视网膜出血与视网膜静脉阻塞最多;所有患者均给予对症治疗,其中23例患者的眼部症状均得到了相应的改善,7例患者的眼部症状无明显改善。结论 SLE合并视网膜病变将对患者的视力造成极大影响,并累及到多器官,病情发展较快,特别是活动期的SLE患者必须接受常规眼底检查,以实现对病情的有效诊断,进而采取相应的治疗办法。
[Abstract]:Objective to summarize the clinical features of (SLE) with retinopathy in systemic lupus erythematosus (SLE). Methods the clinical data of 30 patients with SLE complicated with retinopathy were retrospectively analyzed. Results all the 30 patients were accompanied with different degrees of involvement of other organs of the body. The proportion of patients involved in skin was the highest (70.00,000), followed by renal lesion and central nervous system injury (46.6773.33respectively). All patients were active lupus, with moderate activity being the most, accounting for 70. 00g. After laboratory examination, all patients showed positive antinuclear antibody (ANA), and among them, Anti-double-stranded DNA was positive in 18 patients (60.00%) and anticardiolipin antibody was positive in 10 patients (33.33%). In 30 cases, 44 eyes were involved, 28 cases were accompanied with different degree of vision decline, and 7 cases came to hospital because of visual acuity decline. The visual acuity of 22 eyes was 0.1 卤0.5, and 14 eyes was 0.5 or above, and the visual acuity was better than 0.5 in 14 eyes, the visual acuity of 22 eyes was 0.5 and the vision of 14 eyes was better than 0.5. The visual acuity of the other 8 eyes was below 0.1; For eye lesions, 30 eyes showed the most retinal plaques, retinal hemorrhage and retinal vein occlusion. All the patients were given symptomatic treatment, among them, 23 cases had the corresponding improvement of ocular symptoms, and 7 cases had no obvious improvement. Conclusion SLE combined with retinopathy will have a great impact on the visual acuity of the patients, and will involve multiple organs, and the disease will develop rapidly. In particular, the patients with active SLE must undergo routine fundus examination in order to realize the effective diagnosis of the disease. And then take the corresponding treatment.
【作者单位】：深圳市第二人民医院风湿免疫科;
【分类号】：R593.241;R774.1

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