巩膜扩张术治疗兔老视的安全性和有效性

发布时间：2019-01-22 21:26

【摘要】：目的探讨巩膜扩张术治疗老视的安全性和有效性及其可能作用机制。方法对选择健康有色家兔30只随机分为正常组和实验组,正常组6只进行正常值测定,实验组随机分为3组,第1组行标准巩膜扩张术(SRP),第2组行水平前睫状巩膜切开术(ACS),第3组行放射前睫状巩膜切开术(ACS),测定术前,术后1 d、1 w、1个月的屈光度、调节幅度及巩膜扩张程度,术后1个月进行术区巩膜的病理检查。结果手术前后实验各组屈光度均有不同程度下降(P0.01);缩瞳前与缩瞳后的屈光度改变有显著性差异(P0.01);在术后的不同时期内,各组的屈光度变化无显著差异(P0.05)。术后各组的调节幅度均明显高于术前(P0.01)。实验各组术后的巩膜扩张程度与调节幅度变化均无明显的线性关系。结论SRP和ACS均使兔眼向近视方向发展的趋势;本实验中的3种手术方法均能显著提高兔眼的调节幅度;SRP中可以用硅胶替代PMMA作为巩膜扩张带;ACS采用水平状切口较放射状切口术后调节力的提高更明显、更稳定,因此水平前睫状巩膜切开术可以替代经典的ACS。
[Abstract]:Objective to investigate the safety and efficacy of scleral dilatation in the treatment of presbyopia and its possible mechanism. Methods 30 healthy colored rabbits were randomly divided into normal group and experimental group, and 6 normal rabbits were measured. The experimental group was randomly divided into 3 groups. The first group was treated with standard scleral dilatation (SRP),). Group 2 underwent horizontal anterior ciliary scleral incision (ACS),). Group 3 underwent radioscleral surgery (ACS),). The diopter, amplitude of adjustment and sclera dilatation were measured 1 day and 1 week after operation. Sclera was examined 1 month after operation. Results the diopter decreased in different degree before and after operation (P0.01), and the diopter changes before and after pupil constriction were significantly different (P0.01). There was no significant difference in the diopter of the groups in different period after operation (P 0.05). The adjustment range of each group was significantly higher than that of preoperation (P0.01). There was no significant linear relationship between scleral dilatation and the amplitude of regulation. Conclusion both SRP and ACS can promote myopia in rabbit eyes, the three surgical methods in this experiment can significantly improve the adjustment amplitude of rabbit eyes, silicone gel can be used as scleral dilatation zone instead of PMMA in SRP. Horizontal incision is more stable and more stable than horizontal incision in ACS, so horizontal anterior ciliary scleral incision can replace classical ACS..
【作者单位】：佳木斯大学附属第一医院眼科;
【基金】：黑龙江自然科学基金资助项目(D0217)
【分类号】：R779.6

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