某航校飞行学员高频听力损失研究

发布时间：2019-01-24 09:25

【摘要】：目的跟踪某航校飞行学员人群连续两年的高频听力变化,根据结果判断其变化趋势并进行基因组学筛查,探讨mtDNA4977缺失与噪声性听力损失关系。方法随机抽取某航校2009级140名飞行学员进行听力学检测,连续跟踪调研两年,着重观察个体两年间左右耳高频频段4000、6000、8000Hz之间的听阈值及高频听力累加值的变化情况,针对筛查出的听力下降学员进行mtDNA4977片段缺失情况诊断,应用SPSS19.0统计软件进行同一人群配对样本T检验以验证是否具有统计学意义,以X2检验进行组间基因缺失频率的比较。结果在调查的飞行学员人群中,两年间右耳4000Hz频段有明显变化(p0.05),其他各高频频段及高频听力累加值无明显统计学意义(p0.05)。两组mtD-NA4977缺失率差异有统计学意义(P0.05)。结论在高年级飞行学员人群中存在噪声性听力损失,携带mtDNA4977缺失基因型的个体对噪声性听力损失易感。
[Abstract]:Objective to investigate the relationship between mtDNA4977 deficiency and noise-induced hearing loss by tracking the changes of high-frequency hearing in the flight cadets of a certain aviation school for two consecutive years, judging the trend of the changes and conducting genomics screening. Methods one hundred and forty flight cadets from a certain aviation school were randomly selected for audiological examination and followed up for two consecutive years. The changes of hearing threshold and cumulative value of high frequency hearing between 4 000 and 6 000 Hz were observed in two years. In order to diagnose the mtDNA4977 fragment deletion of hearing impaired students, the T test of paired samples of the same population was carried out by SPSS19.0 statistical software to verify whether there was statistical significance, and the frequency of gene deletion between groups was compared by X2 test. Results there were significant changes in the 4000Hz frequency of the right ear during the two years (p0. 05), but there was no significant difference between the other high frequency bands and the cumulative value of high frequency hearing (p0. 05). There was significant difference in mtD-NA4977 deletion rate between the two groups (P0.05). Conclusion there is noise-induced hearing loss in senior flight cadets, and individuals with mtDNA4977 deletion genotype are susceptible to noise-induced hearing loss.
【作者单位】：河北北方学院;解放军第466医院耳鼻咽喉头颈外科;解放军空军总医院耳鼻咽喉头颈外科;
【基金】：总后十二五重大课题项目(AKJ11J003)
【分类号】：R764

【参考文献】