Ki-67在晚期鼻咽癌中的表达及其与化疗疗效的关系

发布时间：2019-03-07 23:08

【摘要】：目的：研究晚期鼻咽癌组织中ki一67的表达及其与化疗疗效的关系,探讨Ki-67可否作为化疗的敏感预测因子及预测生存的独立预后因素。方法：通过对64例晚期鼻咽癌患者的肿瘤组织中Ki-67的表达与患者的年龄、TNM分期、化疗疗效关系的分析,探讨晚期鼻咽癌患者肿瘤组织中Ki-67的表达对化疗疗效和预后预测等方面的意义。结果：在本研究对象中Ki一67阳性率为70.3%。Ki-67表达与患者年龄、TNM分期不相关(P0.05)。Ki-67低表达组化疗有效率(RR)为88.6%；Ki-67高表达组化疗有效率(RR)为75.9%,两组间比较差异无统计学意义(P0.05)。在使用不同化疗方案化疗时,无论是在PF化疗方案组或非PF化疗方案组均未发现ki-67与化疗疗效间有明显的相关性(P0.05)。远期生存方面,Ki-67低表达组与高表达组比较未显示出明显的生存优势,其1年、3年及5年生存率与高表达组比较差异无统计学意义(P0.05)。结论：在晚期鼻咽癌组织中,Ki-67表达与鼻咽癌患者年龄、TNM分期、及化疗疗效不相关性,与预后亦无明显相关性。因此,Ki-67不能作为晚期鼻咽癌化疗敏感性的预测指标,也不能作为判断晚期鼻咽癌预后的预测指标。
[Abstract]:Aim: to study the expression of Ki-67 in advanced nasopharyngeal carcinoma (NPC) and the relationship between Ki-67 expression and the efficacy of chemotherapy. To explore whether Ki-67 can be used as a sensitive predictor of chemotherapy and an independent prognostic factor in predicting survival. Methods: the relationship between the expression of Ki-67 and the age, TNM stage and curative effect of chemotherapy in 64 cases of advanced nasopharyngeal carcinoma (NPC) was analyzed. To investigate the significance of the expression of Ki-67 in tumor tissue of advanced nasopharyngeal carcinoma (NPC) in predicting the curative effect and prognosis of chemotherapy. Results: the positive rate of Ki-67 was not correlated with the age and TNM stage of the patients (P0.05). The effective rate of chemotherapy was 88.6% in the low expression group of Ki-67. The expression of 70.3%.Ki-67 was not correlated with the age and TNM stage of the patients (P0.05). The effective rate of chemotherapy in Ki-67 high expression group was 75.9%, and there was no significant difference between the two groups (P0.05). There was no significant correlation between ki-67 and the efficacy of chemotherapy in PF chemotherapy group or non-PF chemotherapy group when different chemotherapy regimens were used (P0.05). In terms of long-term survival, there was no significant difference in the 1 -, 3-and 5-year survival rates between the low expression group and the high expression group (P0.05). There was no significant difference between the Ki-67 low expression group and the high expression group (P0.05). Conclusion: in advanced nasopharyngeal carcinoma, the expression of Ki-67 is not correlated with age, TNM stage, chemotherapy effect and prognosis. Therefore, Ki-67 can not be used as a predictor of chemosensitivity of advanced nasopharyngeal carcinoma, nor can it be used as a predictor of prognosis of advanced nasopharyngeal carcinoma.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R739.63

【参考文献】