高眼压性和正常眼压性青光眼P-VEP与视野缺损的相关性研究

发布时间：2019-04-12 19:33

【摘要】：目的探讨高眼压性青光眼(high-tension glaucoma,HTG)和正常眼压性青光眼(normal-tension glaucoma,NTG)图形视觉诱发电位(pattern visual evoked potentials,P-VEP)与视野缺损的相关性。方法选取青光眼患者89例(89眼),其中NTG患者58例,HTG患者31例,对两组患者的一般情况(年龄、性别、屈光度、瞳孔直径等)进行比较分析,所有患者进行常规视野检查,检查指标包括图形标准偏差(pattern standard deviation,PSD)和平均视野缺损(mean defect,MD),另外所有患者行P-VEP检查,观察P100波潜伏期与振幅。同时,对P-VEP的P100波潜伏期和振幅与视野缺损的相关性进行统计分析。结果 NTG组患者的角膜厚度和眼压明显低于HTG组,差异均有统计学意义(均为P0.01);NTG和HTG组患者的P100波潜伏期分别为(115.46±10.83)ms、(116.62±11.47)ms,振幅分别为(9.15±4.36)μV、(8.31±2.94)μV,差异均无统计学意义(均为P0.05);晚期NTG患者的屈光度明显低于HTG组,差异有统计学意义(P=0.04);P-VEP检查的P100波潜伏期与常规视野检查的NTG和HTG患者MD值明显负相关(均为P0.05),而与PSD值则无明显的相关性(均为P0.05)。结论各期HTG和NTG患者间的P100波潜伏期和振幅无明显差异,而视野检查的MD值与P-VEP检查的P100波潜伏期呈负相关。
[Abstract]:Objective to investigate the relationship between pattern visual evoked potential (pattern visual evoked potentials,P-VEP) and visual field defect (VSD) in high tension glaucoma (high-tension glaucoma,HTG) and normal tension glaucoma (normal-tension glaucoma,NTG). Methods 89 patients (89 eyes) with glaucoma were selected, including 58 patients with NTG and 31 patients with HTG. The general conditions (age, sex, diopter, pupil diameter, etc.) of the two groups were compared and analyzed. The parameters included pattern standard deviation (pattern standard deviation,PSD) and mean visual field defect (mean defect,MD). In addition, P-VEP was performed to observe the latency and amplitude of P100 wave. At the same time, the correlation between the latency and amplitude of P100 wave in P-VEP and visual field defect was analyzed statistically. Results the corneal thickness and intraocular pressure in NTG group were significantly lower than those in HTG group (P 0.01). The latency of P100 wave in NTG group and HTG group was (115.46 卤10.83) ms, (116.62 卤11.47) ms, amplitude (9.15 卤4.36) 渭 V and (8.31 卤2.94) 渭 V, respectively (P 0.05). The diopter of late stage NTG patients was significantly lower than that of HTG group (P < 0.05). The latency of P100 wave in P-VEP was negatively correlated with NTG and HTG in conventional visual field (P 0.05), but no significant correlation was found between P100 latency and PD (P 0.05). Conclusion there is no significant difference in the latency and amplitude of P100 wave between patients with HTG and NTG, but there is a negative correlation between the MD value of visual field examination and the latency of P100 wave of P-VEP examination.
【作者单位】：昆明普瑞眼科医院;
【分类号】：R775

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