慢性中耳炎患者真菌感染的治疗

发布时间：2019-04-23 19:09

【摘要】：目的探讨慢性中耳炎患者真菌感染的发病原因、诊断方法及不同治疗方案的疗效。方法分析40例慢性中耳炎真菌感染患者的临床资料,根据慢性中耳炎患者的症状、耳镜检查及真菌鉴定结果等进行诊断,将患者分为局部用药组20例(20耳)和联合用药组20例(20耳),进行疗效评估。结果经治患者随访6个月,局部用药治愈率为40.0%、总有效率85.0%,联合用药组治愈率为75.0%、总有效率90%;联合用药组治愈率明显高于局部用药组,差异有统计学意义(P0.05),但两组总有效率差异无统计学意义。结论慢性中耳炎合并真菌感染与长期滥用抗菌药物及免疫制剂导致菌群失调有关,治疗慢性中耳炎合并真菌感染建议以局部用药为主,辅以氟康唑等口服广谱抗真菌药物。
[Abstract]:Objective to investigate the causes, diagnostic methods and therapeutic effects of fungal infection in patients with chronic otitis media. Methods the clinical data of 40 patients with chronic otitis media fungal infection were analyzed. According to the symptoms of patients with chronic otitis media, the results of otoscope examination and fungal identification were analyzed. The patients were divided into two groups: 20 cases (20 ears) in local medication group and 20 cases (20 ears) in combination group. Results after 6 months of follow-up, the cure rate was 40. 0%, the total effective rate was 85. 0%, the cure rate was 75. 0% and the total effective rate was 90% in the combination group. The cure rate of the combined drug group was significantly higher than that of the local drug group (P0.05), but there was no significant difference in the total effective rate between the two groups. Conclusion chronic otitis media complicated with fungal infection is related to the long-term abuse of antibiotics and immune agents resulting in dysbacteriosis. It is suggested that local drugs should be used mainly in the treatment of chronic otitis media complicated with fungal infection, and fluconazole and other oral broad-spectrum antifungal drugs should be given priority to in the treatment of chronic otitis media complicated with fungal infection.
【作者单位】：海南省农垦总医院耳鼻喉科;
【基金】：海口市科技局基金资助项目(Y20120061)
【分类号】：R764.21

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