鼻渊通窍颗粒对儿童慢性鼻窦炎鼻黏膜纤毛传输功能及炎性因子的影响

发布时间：2019-05-07 13:12

【摘要】：目的:探讨鼻渊通窍颗粒对儿童慢性鼻窦炎患者的临床疗效及作用机制。方法:将120例患者随机按数字法分为对照组和观察组各60例。对照组采用阿莫西林克拉维酸钾干混悬剂,4~7岁,1包/次,2次/d,7~12岁,1.5包/次,2次/d。疗程4周。氨溴索颗粒,1.2~1.6 mg·kg-1,分2~3次口服,疗程6周。标准桃金娘油肠溶胶囊(儿童装),120 mg/次,3次/d。疗程6周。观察组在对照组治疗的基础上加鼻渊通窍颗粒,5~10 g/次,3次/d。疗程6周。检测鼻黏膜纤毛传输时间(MTT);检测血清白细胞介素-2(IL-2)和白细胞介素-6(IL-6)水平;进行鼻内镜检查,采用Lund-Kennedy评分法评价结果;记录治疗前后主要症状、体征评分。结果:观察组疾病疗效总有效率95%,对照组81.7%,观察组优于对照组(P0.05);治疗后观察组IL-2和IL-6水平低于对照组(P0.01);治疗后3个月观察组MTT及Lund-Kennedy评分低于对照组(P0.01);治疗后观察组鼻塞、流脓涕、头痛、嗅觉减退、回吸痰、鼻黏膜充血肿胀等症状、体征评分均低于对照组(P0.01)。结论:鼻渊通窍颗粒能抑制儿童慢性鼻窦炎患者促炎因子,促进鼻黏膜纤毛功能,改善患者临床症状、体征,临床有一定疗效。
[Abstract]:Objective: to investigate the clinical effect and mechanism of Biyuan Tongqiao granule on children with chronic sinusitis. Methods: 120 patients were randomly divided into two groups: control group (n = 60) and observation group (n = 60). The control group was treated with amoxicillin-clavulanate potassium dry suspension, 4 years old, 1 pack per day, 2 times per day, 7-day-old, 12-year-old, 1.5 packets / time, 2 times / d. The course of treatment was 4 weeks. Ambroxol granules, 1.2? 1.6 mg kg-1, were given 3 times for 6 weeks. Standard Taojinniang oil enteric-soluble capsule (children's suit), 120 mg/ times, 3 times / d. The course of treatment was 6 weeks. In the observation group, on the basis of the treatment of the control group, Biyuan Tongqiao granule was added, 5 g / time, 3 times / d. The course of treatment was 6 weeks. The levels of serum interleukin-2 (IL-2) and interleukin-6 (IL-6) were detected by (MTT);, the nasal endoscopy was performed, and the results were evaluated by Lund-Kennedy scoring method, and the levels of serum interleukin-2 (IL-2) and interleukin-6 (IL-6) were measured by RT-PCR. The main symptoms and signs were recorded before and after treatment. Results: the total effective rate was 95% in the observation group and 81.7% in the control group, which was better than that in the control group (P0.05), and the levels of IL-2 and IL-6 in the observation group were lower than those in the control group (P0.01). The scores of MTT and Lund-Kennedy in the observation group were lower than those in the control group 3 months after treatment (P0.01). After treatment, the symptoms such as nasal congestion, runny pus, headache, anosmia, expectoration, congestion and swelling of nasal mucosa in the observation group were lower than those in the control group (P0.01). Conclusion: Biyuan Tongqiao granule can inhibit the proinflammatory factors in children with chronic sinusitis, promote the ciliate function of nasal mucosa, improve the clinical symptoms and signs of the patients, and have a certain clinical effect.
【作者单位】：郑州大学第一附属医院;
【基金】：国家自然科学基金项目(2010A320020)
【分类号】：R765.41

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