HIF-1α、MVD及EGFR表达对鼻内翻性乳头状瘤恶变的诊断意义及紫杉醇干预效果分析

发布时间：2019-05-08 11:56

【摘要】：目的:分析HIF-1α、MVD及EGFR的表达对鼻内翻性乳头状瘤恶变不同阶段的诊断意义及紫杉醇的临床效果。方法:采用免疫组织化学方法检测并定量分析鼻内翻性乳头状瘤、轻度及中重度不典型增生状和恶变组织中HIF-1α、MVD及EGFR的表达情况及三者的相关性,并分析紫杉醇对恶变组织中上述分子的改善作用。结果:HIF-1α、MVD及EGFR的表达随增生及恶化程度的加剧而增强,且鼻内翻性乳头状瘤、轻度及中重度不典型增生状组织中HIF-1α、MVD及EGFR的表达具有显著的统计学差异性(P0.01),HIF-1α与MVD及EGFR表达呈正相关性。紫杉醇可显著改善恶变组织中HIF-1α、MVD及EGFR的表达,且紫杉醇治疗后与中重度不典型增生状组织表达无显著的统计学差异性(P0.05)。结论:HIF-1α、MVD及EGFR参与了鼻内翻性乳头状瘤的发生、增生及恶化过程,可以作为临床诊断鼻内翻性乳头状瘤增生及恶化的标志物。
[Abstract]:Aim: to analyze the significance of the expression of HIF-1 伪, MVD and EGFR in the diagnosis of malignant transformation of nasal inverted papilloma and the clinical effect of paclitaxel. Methods: immunohistochemical method was used to detect and quantitatively analyze the expression of HIF-1 伪, MVD and EGFR in nasal inverted papilloma, mild, moderate and severe atypical hyperplasia and malignant lesions. The improvement effect of paclitaxel on the above molecules in malignant tissue was analyzed. Results: the expression of HIF-1 伪, MVD and EGFR in nasal inverted papilloma, mild and moderate to severe atypical hyperplasia tissues were increased with the aggravation of hyperplasia and aggravation, and the expression of HIF-1 伪 in nasal inverted papilloma, mild and moderate to severe dysplasia. The expression of MVD and EGFR was significantly different (P0.01). There was a positive correlation between HIF-1 伪 and MVD and EGFR. Paclitaxel could significantly improve the expression of HIF-1 伪, MVD and EGFR in malignant tissues, and there was no significant difference between paclitaxel treatment and moderate and severe atypical hyperplasia tissues (P0.05). Conclusion: HIF-1 伪, MVD and EGFR are involved in the occurrence, proliferation and deterioration of nasal inverted papilloma, and can be used as markers for clinical diagnosis of nasal inverted papilloma.
【作者单位】：贵州省黔西南州人民医院耳鼻咽喉科;
【分类号】：R739.62

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