早期喉癌手术阴性切缘组织中PCNA、COX-2表达与肿瘤局部复发的关系

发布时间：2019-05-08 17:19

【摘要】：目的探讨早期喉癌手术阴性切缘组织中PCNA、COX-2的表达与肿瘤局部复发的关系。方法选择63例经CO2激光手术治疗后的早期喉癌患者标本,对切除的肿瘤组织及切缘组织中PCNA、COX-2表达进行检测,所有患者均随访2年以上,对其生存及肿瘤复发情况进行观察。结果 63例早期喉癌患者肿瘤组织中PCNA、COX-2阳性率分别为73.02%、71.43%;切缘组织中PCNA和COX-2阳性率分别为33.33%、30.16%。肿瘤组织与切缘组织中PCNA、COX-2均阳性的患者分别为41例和13例,阳性率分别为65.08%、20.63%;63例随访病例中,局部复发17例,复发率为26.98%。PCNA阳性患者复发率为71.43%,COX-2阳性患者复发率为73.68%(P0.05)。联合检测PCNA和COX-2阳性者复发率明显高于单独阳性者(P0.05)。结论早期喉癌手术切缘组织中PCNA、COX-2的表达是喉癌患者预后的重要生物学标志,并可根据检查结果制定针对性的后续治疗方案,联合检测二者对术后治疗具有更可靠的指导意义。
[Abstract]:Objective to investigate the relationship between the expression of PCNA,COX-2 in negative margin of early laryngeal carcinoma and local recurrence of laryngeal carcinoma. Methods the expression of PCNA,COX-2 was detected in 63 cases of early laryngeal carcinoma treated by CO2 laser. All the patients were followed up for more than 2 years. The survival and tumor recurrence were observed. Results the positive rates of PCNA,COX-2 and COX-2 in 63 patients with early laryngeal carcinoma were 73.02% and 41.43% respectively, and those in incised margin tissues were 33.33% and 30.16%, respectively. The positive rate of PCNA,COX-2 was 65.08% and 20.63% in 41 cases and 13 cases of tumor tissue and incisor margin tissue, respectively, and the positive rate was 65.08% and 20.63%, respectively. The recurrence rate of 26.98%.PCNA positive patients was 71.43%, and that of Cox-2 positive patients was 73.68% (P0.05). The recurrence rate of PCNA and COX-2 positive group was significantly higher than that of single positive group (P 0.05). Conclusion the expression of PCNA,COX-2 in the surgical margin of early laryngeal carcinoma is an important biological marker for prognosis of laryngeal carcinoma, and it can be used as a follow-up therapy according to the results of examination. Combined detection has more reliable guiding significance for postoperative treatment.
【作者单位】：河北省唐山市协和医院病理科;河北省唐山市人民医院放化科;
【分类号】：R739.65

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