鼻咽癌适形调强放疗中涎腺功能的全面保护

发布时间：2019-05-20 10:04

【摘要】：目的:探讨鼻咽癌适形调强放疗(intensity modulate radiation therapy,IMRT)患者各涎腺功能的保护方法。方法:选取2010年3月至2012年11月101例连续于中山大学肿瘤医院接受IMRT鼻咽癌患者,勾画危及器官,包括腮腺、颌下腺、口腔,于3、6、12、18、24个月复查时采用面对面访谈式问卷调查评分口干程度情况,并结合剂量体积直方图(dose-volume histograms,DVH)进行分析。结果:腮腺平均剂量(MD)为37.4 Gy(患侧),33.8 Gy(健侧);颌下腺MD为51.6 Gy(患侧),45.7 Gy(健侧);口腔MD为38.2 Gy。77.2%(78/101)患者放疗结束后6个月口干症状明显改善,1年后中度(G3)以上口干患者5.0%(5/101)。结论:随着时间的推移,放疗后口干燥症明显改善;限定至少一侧腮腺V30~35≤50.0%,至少一侧颌下腺V40~45≤66.7%~50.0%,口腔MD40 Gy可有效保护唾液腺功能。
[Abstract]:Objective: to investigate the protective method of salivary gland function in patients with nasopharyngeal carcinoma (NPC) treated with conformal intensity modulation radiotherapy (intensity modulate radiation therapy,IMRT). Methods: from March 2010 to November 2012, 101 consecutive patients with IMRT nasopharyngeal carcinoma were enrolled in the Cancer Hospital of Sun Yat-sen University. In 12, 18, 24 months of review, face-to-face interview questionnaire was used to evaluate the dryness of the mouth, and the dose volume histogram (dose-volume histograms,DVH) was used to analyze the dry degree of the mouth. Results: the average dose of (MD) was 37.4 Gy (affected side) and 33.8 Gy (healthy side), and the MD of submandibular gland was 51.6 Gy (affected side) and 45.7 Gy (healthy side), respectively. The symptoms of dry mouth were significantly improved in patients with oral MD of 38.2 Gy.77.2% (78 鈮，

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