急性区域性隐匿性外层视网膜病变频域光学相干断层扫描图像的特征分析
发布时间：2019-05-22 22:05
【摘要】：目的观察急性区域性隐匿性外层视网膜病变(acute zonal occult outer retinopathy,AZOOR)的频域光学相干断层扫描图像(optical coherence tomography,OCT)的特征。方法临床确诊为AZOOR患者5例(5眼)纳入研究,健眼为对照眼。所有患者均行最佳矫正视力检查,并行OCT检查患者的黄斑区,观察并分析患者的OCT图像特征,并和健眼比较分析黄斑区的厚度差异和结构改变。结果 OCT检查提示患者存在不同程度的视网膜外层损害,损害的位置和范围不同,其共同特征是外界膜层光带信号强度不均匀,局部显示模糊甚至局部缺损,局部区域向下凹陷。光感受器内节/外节光带出现强度减弱和部分区域断裂、消失的现象。而在几乎所有的患眼病变区域视锥细胞外节尖端层模糊或消l 失,视网膜色素上皮层则没有显著的结构改变。患眼中心凹处外界膜-视网膜色素上皮层厚度为(83.20±9.90)μm,健眼为(101.80±2.23)μm,差异有统计学意义(t=-4.09,P0.05)。Pearson相关分析显示患眼与健眼外界膜-视网膜色素上皮层厚度的差值,与患眼BCVA呈负相关(r=-0.94,P0.05)。结论 AZOOR患者的视网膜损害多位于外层,其中视锥细胞外节尖端层损害最为显著;患者均有不同程度的外界膜层至视网膜色素上皮层变薄的现象,可能是导致患者视力下降的主要原因。
[Abstract]:Objective to observe the characteristics of frequency domain optical coherence tomography (optical coherence tomography,OCT) in acute regional occult outer retinal disease (acute zonal occult outer retinopathy,AZOOR). Methods five patients (5 eyes) with AZOOR were included in the study, and the healthy eyes were used as control eyes. The best corrected visual acuity was performed in all patients, and the macular area was examined by OCT. The OCT image features of the patients were observed and analyzed, and the thickness difference and structural changes of macular area were compared with those of healthy eyes. Results OCT showed that there were different degrees of retinal outer layer damage, and the location and scope of the damage were different. The common characteristics were uneven signal intensity of external film light band, local blurred or even local defect, and local depression. The intensity of the inner / outer segment of the photoreceptor is weakened and some areas are broken and disappeared. However, in almost all the affected areas, the tip of the cone was blurred or lost, while there was no significant structural change in the retinal pigment epithelial layer. The thickness of outer membrane-retinal pigment epithelial layer in the central concave of the affected eyes was (83. 20 卤9. 90) 渭 m, and that of the healthy eyes was (101.80 卤2. 23) 渭 m, the difference was statistically significant (t 鈮，
本文编号：2483307
[Abstract]:Objective to observe the characteristics of frequency domain optical coherence tomography (optical coherence tomography,OCT) in acute regional occult outer retinal disease (acute zonal occult outer retinopathy,AZOOR). Methods five patients (5 eyes) with AZOOR were included in the study, and the healthy eyes were used as control eyes. The best corrected visual acuity was performed in all patients, and the macular area was examined by OCT. The OCT image features of the patients were observed and analyzed, and the thickness difference and structural changes of macular area were compared with those of healthy eyes. Results OCT showed that there were different degrees of retinal outer layer damage, and the location and scope of the damage were different. The common characteristics were uneven signal intensity of external film light band, local blurred or even local defect, and local depression. The intensity of the inner / outer segment of the photoreceptor is weakened and some areas are broken and disappeared. However, in almost all the affected areas, the tip of the cone was blurred or lost, while there was no significant structural change in the retinal pigment epithelial layer. The thickness of outer membrane-retinal pigment epithelial layer in the central concave of the affected eyes was (83. 20 卤9. 90) 渭 m, and that of the healthy eyes was (101.80 卤2. 23) 渭 m, the difference was statistically significant (t 鈮，
本文编号：2483307
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