阻塞性睡眠呼吸暂停低通气综合征患者睡眠结构紊乱与肝酶水平升高的相关性研究
发布时间：2019-05-23 01:05
【摘要】：目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的睡眠结构紊乱及其对肝酶水平的影响。方法研究2010—2013年苏州大学附属第二医院神经内科收治的多导睡眠监测(PSG)确诊的OSAHS组和对照组的睡眠参数,且根据睡眠呼吸暂停和(或)低通气指数(AHI)将OSAHS组分为轻、中、重度三组,比较各组间肝酶及睡眠结构的变化,并将肝酶水平与睡眠结构指标进行相关性分析。结果与对照组比较,OSAHS组患者的AHI、呼吸相关微觉醒指数、最长呼吸暂停时间、睡眠时间1+2期比例及血清丙氨酸转氨酶(ATL)、天冬氨酸转氨酶(ASL)、血清γ-谷氨酰转肽酶(γ-GGT)水平显著增高,最低血氧饱和度(L-SaO2)及慢波睡眠比例显著降低(均P0.05)。OSAHS组各亚组间比较,AHI差异有统计学意义;与重度亚组比较,轻、中度亚组呼吸相关微觉醒指数、最长呼吸暂停时间、睡眠时间1+2期比例、慢波睡眠比例及血清ATL、ASL的变化均有统计学意义;与重度亚组比较,轻度亚组的血清γ-GGT显著升高(P0.05)。偏相关分析显示,血清ALT、AST与睡眠1+2期比例呈正相关,血清ALT与慢波睡眠比例呈负相关,与呼吸睡眠微觉醒呈正相关(均P0.05)。结论 OSAHS患者存在睡眠结构紊乱及肝脏损伤,其肝酶水平的升高与睡眠结构紊乱有关。
[Abstract]:Objective to study the disorder of sleep structure and its effect on liver enzyme level in patients with obstructive sleep Apnea hypopnea syndrome (OSAHS). Methods the sleep parameters of OSAHS group and control group diagnosed by (PSG) were studied in the Department of Neurology, the second affiliated Hospital of Suzhou University from 2010 to 2013. The OSAHS group was divided into mild group according to sleep apnea and / or hypopnea index (AHI). In moderate and severe groups, the changes of liver enzyme and sleep structure were compared, and the correlation between liver enzyme level and sleep structure index was analyzed. Results compared with the control group, the AHI, respiratory related microarousal index, the longest apnea time, the proportion of sleep time in 12 stages and the serum alanine transaminase (ATL), aspartate transaminase (ASL), in the OSAHS group were compared with those in the control group. The level of serum gamma-glutamyl transpeptidase (纬-GGT) was significantly increased, the lowest oxygen saturation (L-SaO2) and the proportion of slow wave sleep were significantly decreased (P 0.05). There was significant difference in AHI among each subgroup of). OSAHS group. Compared with the severe subgroup, the respiratory related microarousal index, the longest apnea time, the proportion of sleep time in 12 stages, the proportion of slow wave sleep and the change of serum ATL,ASL in mild and moderate subgroup were statistically significant. Compared with the severe subgroup, the serum 纬-GGT in the mild subgroup was significantly higher than that in the severe subgroup (P 0.05). Partial correlation analysis showed that serum ALT,AST was positively correlated with the proportion of sleep stage 12, serum ALT was negatively correlated with the proportion of slow wave sleep, and positively correlated with respiratory sleep microarousal (all P 0.05). Conclusion there are sleep structure disorder and liver injury in patients with OSAHS, and the increase of liver enzyme level is related to sleep structure disorder.
【作者单位】： 苏州大学附属第二医院神经内科;
【基金】：国家自然科学基金(81200894) 教育部高等学校博士学科点专项科研基金(20113201120016)
【分类号】：R766
，
本文编号：2483458
[Abstract]:Objective to study the disorder of sleep structure and its effect on liver enzyme level in patients with obstructive sleep Apnea hypopnea syndrome (OSAHS). Methods the sleep parameters of OSAHS group and control group diagnosed by (PSG) were studied in the Department of Neurology, the second affiliated Hospital of Suzhou University from 2010 to 2013. The OSAHS group was divided into mild group according to sleep apnea and / or hypopnea index (AHI). In moderate and severe groups, the changes of liver enzyme and sleep structure were compared, and the correlation between liver enzyme level and sleep structure index was analyzed. Results compared with the control group, the AHI, respiratory related microarousal index, the longest apnea time, the proportion of sleep time in 12 stages and the serum alanine transaminase (ATL), aspartate transaminase (ASL), in the OSAHS group were compared with those in the control group. The level of serum gamma-glutamyl transpeptidase (纬-GGT) was significantly increased, the lowest oxygen saturation (L-SaO2) and the proportion of slow wave sleep were significantly decreased (P 0.05). There was significant difference in AHI among each subgroup of). OSAHS group. Compared with the severe subgroup, the respiratory related microarousal index, the longest apnea time, the proportion of sleep time in 12 stages, the proportion of slow wave sleep and the change of serum ATL,ASL in mild and moderate subgroup were statistically significant. Compared with the severe subgroup, the serum 纬-GGT in the mild subgroup was significantly higher than that in the severe subgroup (P 0.05). Partial correlation analysis showed that serum ALT,AST was positively correlated with the proportion of sleep stage 12, serum ALT was negatively correlated with the proportion of slow wave sleep, and positively correlated with respiratory sleep microarousal (all P 0.05). Conclusion there are sleep structure disorder and liver injury in patients with OSAHS, and the increase of liver enzyme level is related to sleep structure disorder.
【作者单位】： 苏州大学附属第二医院神经内科;
【基金】：国家自然科学基金(81200894) 教育部高等学校博士学科点专项科研基金(20113201120016)
【分类号】：R766
，
本文编号：2483458
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