小梁切除术联合MMC及生物羊膜移植可调整缝线治疗难治性青光眼的临床观察
发布时间：2019-06-13 15:47
【摘要】： 目的探讨小梁切除术联合丝裂霉素C(MMC)及生物羊膜移植可调整缝线治疗难治性青光眼的效果。方法将接受小梁切除术的各类型难治性青光眼38例(44眼)分为3组,A组为治疗组(16眼),巩膜瓣下行羊膜移植术(AMT)联合应用MMC；B组为MMC组(14眼),巩膜瓣下联合应用MMC;C组为对照组(14眼),常规行单纯小梁切除术；3组病例均留置可调整缝线。术后1周、2周、1月、6月、12月观察记录术眼眼压、滤过泡、前房深度情况及并发症。结果术后眼压、滤过泡、前房深度情况及并发症治疗组、MMC组均好于对照组,组间差异有统计学意义(P0.01)。术后并发症：治疗组少,主要有术后浅前房；MMC组主要有薄壁滤过泡、滤过泡渗漏等。结论小梁切除术联合MMC及生物羊膜移植可调整缝线是治疗难治青光眼的一种有效方法,羊膜植入不仅有抗新生血管和抗瘢痕形成的作用,而且早期还有机械引流的作用。
[Abstract]:Objective To study the effect of trabeculectomy combined with mitomycin C (MMC) and biological amnion transplantation in the treatment of refractory glaucoma. Methods 38 cases of refractory glaucoma with trabeculectomy (44 eyes) were divided into 3 groups, group A was treated group (16 eyes), scleral flap descending amniotic membrane transplantation (AMT) combined with MMC, group B was MMC group (14 eyes), and MMC was used in scleral flap. In group C, the control group (14 eyes) and the conventional simple trabeculectomy were performed, and the adjustable suture was retained in the 3 cases. Intraocular hypertension, bleb, anterior chamber depth and complications were recorded at 1 week,2 weeks, January, June and December after operation. Results The intraocular pressure, the bleb, the depth of the anterior chamber, the treatment group of the complication and the MMC group were better than those in the control group, and the difference between the groups was statistically significant (P0.01). The postoperative complications were as follows: the treatment group was few, mainly had the post-operative shallow anterior chamber; the MMC group mainly had a thin-wall filtration bubble, a filtered bubble leak, and the like. Conclusion Trabeculectomy combined with MMC and bioamnion transplantation can be an effective method for the treatment of refractory glaucoma.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R779.6
本文编号：2498623
[Abstract]:Objective To study the effect of trabeculectomy combined with mitomycin C (MMC) and biological amnion transplantation in the treatment of refractory glaucoma. Methods 38 cases of refractory glaucoma with trabeculectomy (44 eyes) were divided into 3 groups, group A was treated group (16 eyes), scleral flap descending amniotic membrane transplantation (AMT) combined with MMC, group B was MMC group (14 eyes), and MMC was used in scleral flap. In group C, the control group (14 eyes) and the conventional simple trabeculectomy were performed, and the adjustable suture was retained in the 3 cases. Intraocular hypertension, bleb, anterior chamber depth and complications were recorded at 1 week,2 weeks, January, June and December after operation. Results The intraocular pressure, the bleb, the depth of the anterior chamber, the treatment group of the complication and the MMC group were better than those in the control group, and the difference between the groups was statistically significant (P0.01). The postoperative complications were as follows: the treatment group was few, mainly had the post-operative shallow anterior chamber; the MMC group mainly had a thin-wall filtration bubble, a filtered bubble leak, and the like. Conclusion Trabeculectomy combined with MMC and bioamnion transplantation can be an effective method for the treatment of refractory glaucoma.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R779.6
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