射频热凝治疗变应性鼻炎对血清与鼻黏膜中神经肽的影响

发布时间：2019-06-25 17:22

【摘要】：目的:本研究旨在探讨射频热凝双侧翼管、筛前神经丛集区对变应性鼻炎(AR)血清及鼻黏膜中神经肽的影响。方法:在2009年11月至2010年9月期间从医院随机选取18名AR患者接受双侧翼管、筛前神经丛集区射频热凝术。分别在术前和术后2月用ELIA检测血清P物质(SP)、血管活性肠肽(VIP)和神经肽Y(NPY)水平,同时用免疫组化检测鼻黏膜中此三种神经肽水平。结果:血清中SP、VIP和NPY水平在术前分别为63.46±12.68 ng/ml、32.46±17.49 ng/ml、10.51±4.27 pg/ml,术后分别为38.44±14.21 ng/ml、14.76±8.01 ng/ml、4.81±2.62 pg/ml。通过免疫组化发现术后鼻黏膜中SP、VIP和NPY水平都显著下降(P0.05)。结论:目前数据表明双侧翼管、筛前神经丛集区射频热凝治疗AR能减少血清及鼻黏膜中SP、VIP和NPY水平。本研究支持了该手术是治疗AR有效果手段这一观点。
[Abstract]:Objective: to investigate the effects of radiofrequency thermocoagulation of bilateral pterygoid tube and anterior ethmoidal nerve cluster on neuropeptides in serum and nasal mucosa of allergic rhinitis (AR). Methods: from November 2009 to September 2010, 18 patients with AR were randomly selected for radiofrequency thermocoagulation of bilateral pterygoid tube and anterior ethmoidal nerve cluster area. The levels of serum substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) were detected by ELIA before operation and 2 months after operation, and the levels of these three neuropeptides in nasal mucosa were detected by immunohistochemistry. Results: the levels of SP,VIP and NPY in serum were 63.46 卤12.68 ng/ml,32.46 卤17.49 ng/ml,10.51 卤4.27 pg/ml, and 38.44 卤14.21 ng/ml,14.76 卤8.01 ng/ml,4.81 卤2.62 pg/ml., respectively. The levels of SP,VIP and NPY in nasal mucosa decreased significantly after operation (P 0.05). Conclusion: the current data show that radiofrequency thermocoagulation in bilateral pterygoid tube and anterior ethmoidal nerve cluster area can reduce the levels of SP,VIP and NPY in serum and nasal mucosa. This study supports the view that the operation is effective in the treatment of AR.
【学位授予单位】：桂林医学院
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R765.21

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