角膜后部多形性营养不良合并高度近视病例分析
发布时间：2019-07-02 12:45
【摘要】： 1.背景与目的 角膜后部多形性营养不良(posterior polymorphous corneal dystrophy, PPCD)是一种罕见的、双侧角膜内皮及深基质层多形性改变的角膜后部营养不良,该病通常为常染色体显性遗传,亦有部分为常染色体隐性遗传,国内目前仅有一家系2例被报道。高度近视是较常见的眼屈光不正疾病,在我国有较高的发病率和致盲率。目前认为其发病可能是遗传因素与环境因素共同作用的结果。本文结合一例PPCD合并高度近视病例的报道和随访,着重总结和分析PPCD的临床表现、诊疗现状及发病机制,以提高对PPCD的认识,同时探讨PPCD与高度近视两者之间可能存在的联系。 2.材料和方法 分析浙江大学医学院附属第一医院2004年10月确诊并随访5年的一例PPCD合并高度近视的病例,查找美国国立图书馆PubMed、万方数据资源系统、维普期刊在线数据库的相关文献,进行文献复习。 3.结果和结论 本文病例的发病年龄、临床表现、裂隙灯检查、角膜内皮镜、共焦显微镜检查的结果符合典型泡状病变型PPCD。医学验光结果的变化、眼轴长度的变化、眼底表现符合高度近视的诊断。角膜内皮镜及共焦显微镜检查有助于PPCD的诊断和病情评估。PPCD和高度近视的关系目前尚不明确,可能为相互独立的两个疾病,亦可能具有某些共同的致病机制。
[Abstract]:1. Background and objective posterior corneal pleomorphic dystrophy (posterior polymorphous corneal dystrophy, PPCD) is a rare posterior corneal dystrophy with bilateral corneal endothelial and deep stroma pleomorphism. The disease is usually autosomal dominant and partly autosomal recessive. At present, only 2 cases have been reported in one family in China. High myopia is a common ametropia, which has a high incidence and blindness rate in China. At present, it is considered that the pathogenesis may be the result of the interaction of genetic factors and environmental factors. Based on the report and follow-up of a case of PPCD complicated with high myopia, this paper focuses on the summary and analysis of the clinical manifestations, diagnosis and treatment status and pathogenesis of PPCD in order to improve the understanding of PPCD and explore the possible relationship between PPCD and high myopia. two銆，
本文编号：2508939
[Abstract]:1. Background and objective posterior corneal pleomorphic dystrophy (posterior polymorphous corneal dystrophy, PPCD) is a rare posterior corneal dystrophy with bilateral corneal endothelial and deep stroma pleomorphism. The disease is usually autosomal dominant and partly autosomal recessive. At present, only 2 cases have been reported in one family in China. High myopia is a common ametropia, which has a high incidence and blindness rate in China. At present, it is considered that the pathogenesis may be the result of the interaction of genetic factors and environmental factors. Based on the report and follow-up of a case of PPCD complicated with high myopia, this paper focuses on the summary and analysis of the clinical manifestations, diagnosis and treatment status and pathogenesis of PPCD in order to improve the understanding of PPCD and explore the possible relationship between PPCD and high myopia. two銆，
本文编号：2508939
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