鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症1例报道并文献复习
发布时间：2021-03-03 07:30
<正>0引言结外NK/T细胞淋巴瘤是一种原发于鼻腔的正常淋巴细胞异常激活和（或）异常分化的恶性肿瘤,其中鼻腔是常见部位,也可发生在皮肤、胃肠道、肺、心脏等部位[1-3]。结外NK/T细胞淋巴瘤易并发嗜血细胞综合征（hemophagocytic syndrome,HPS）,但合并传染性单核细胞增多症（infectious mononucleosis,IM）的概率较低,国内外未见报
【文章来源】：肿瘤防治研究. 2015,42(09)北大核心
【文章页数】：3 页
【部分图文】：
鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽CT影像学表现Figure1NasopharyngealCTimagingofpatientwithnasal
感染是这类肿瘤的病因。本例患者发病时也具有EBV含量增高，给予DICE+L-asp的方案治疗后EBV含量下降，PET-CT提示完全缓图1鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽CT影像学表现Figure1NasopharyngealCTimagingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA:Theconventionaldyeingoflymphnodelesions(HE×200);B:ThenegativeexpressionofCD20(IHC×200);C:ThepositiveexpressionofKi-67(IHC×200);D:ThepositiveexpressionofCD56(IHC×200)图2鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者病理常规及免疫组织化学Figure2PathologicalandimmunohistochemicalstainingofthepatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy图3鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽18F-FDGPET-CT影像学表现Figure3Nasopharyngeal18F-FDGPET-CTimagingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA,B:Differentviewsofthesamecells图4鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者外周血细胞形态（瑞士-吉姆萨染色×1000）Figure4PeripheralbloodcellmorphologyofpatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy(Switzerland-Giemsastaining×1000)A,B:Differentviewsofthesamecells图5鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者骨髓细胞形态（瑞士吉姆萨染色×1000）Figure5BonemarrowcellsmorphologyofpatientwithnasalNK/Tcelllymphomac
gingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA:Theconventionaldyeingoflymphnodelesions(HE×200);B:ThenegativeexpressionofCD20(IHC×200);C:ThepositiveexpressionofKi-67(IHC×200);D:ThepositiveexpressionofCD56(IHC×200)图2鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者病理常规及免疫组织化学Figure2PathologicalandimmunohistochemicalstainingofthepatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy图3鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽18F-FDGPET-CT影像学表现Figure3Nasopharyngeal18F-FDGPET-CTimagingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA,B:Differentviewsofthesamecells图4鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者外周血细胞形态（瑞士-吉姆萨染色×1000）Figure4PeripheralbloodcellmorphologyofpatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy(Switzerland-Giemsastaining×1000)A,B:Differentviewsofthesamecells图5鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者骨髓细胞形态（瑞士吉姆萨染色×1000）Figure5BonemarrowcellsmorphologyofpatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy(Switzerland-Giemsastaining×1000)
【参考文献】：
期刊论文
[1]原发心脏淋巴瘤的临床病理特征及治疗分析[J]. 董菲,李敏,景红梅,王晶,克晓燕. 肿瘤防治研究. 2015(07)
[2]NK/T细胞淋巴瘤患者中血浆EB病毒含量检测及其临床意义[J]. 刘阳,林全德,刘玉章,赵俊梅,王超,喻凤宽,张龑莉,李玉富,房佰俊. 中国实用医药. 2014(02)
[3]儿童传染性单核细胞增多症多个临床检测指标的诊断价值[J]. 伏洁,崔红,周士新. 武警医学. 2013(09)
[4]成人传染性单核细胞增多症患者56例临床及实验室特征分析[J]. 谢杨新,秦恩强,李文刚,许文,徐哲,张昕,周志平,陈威巍,聂为民,赵敏. 疑难病杂志. 2013(07)
[5]儿童EB病毒感染相关性噬血细胞综合征临床特点分析[J]. 郭霞,李强,周晨燕,赵亚宁. 中国实验血液学杂志. 2013(02)
[6]儿童传染性单核细胞增多症96例诊治体会[J]. 雷玲侠,刘小乖,李亚绒. 陕西医学杂志. 2012(09)
[7]淋巴瘤相关性噬血细胞综合征一例[J]. 谭松. 中国全科医学. 2010(14)
本文编号：3060874
【文章来源】：肿瘤防治研究. 2015,42(09)北大核心
【文章页数】：3 页
【部分图文】：
鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽CT影像学表现Figure1NasopharyngealCTimagingofpatientwithnasal
感染是这类肿瘤的病因。本例患者发病时也具有EBV含量增高，给予DICE+L-asp的方案治疗后EBV含量下降，PET-CT提示完全缓图1鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽CT影像学表现Figure1NasopharyngealCTimagingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA:Theconventionaldyeingoflymphnodelesions(HE×200);B:ThenegativeexpressionofCD20(IHC×200);C:ThepositiveexpressionofKi-67(IHC×200);D:ThepositiveexpressionofCD56(IHC×200)图2鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者病理常规及免疫组织化学Figure2PathologicalandimmunohistochemicalstainingofthepatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy图3鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽18F-FDGPET-CT影像学表现Figure3Nasopharyngeal18F-FDGPET-CTimagingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA,B:Differentviewsofthesamecells图4鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者外周血细胞形态（瑞士-吉姆萨染色×1000）Figure4PeripheralbloodcellmorphologyofpatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy(Switzerland-Giemsastaining×1000)A,B:Differentviewsofthesamecells图5鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者骨髓细胞形态（瑞士吉姆萨染色×1000）Figure5BonemarrowcellsmorphologyofpatientwithnasalNK/Tcelllymphomac
gingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA:Theconventionaldyeingoflymphnodelesions(HE×200);B:ThenegativeexpressionofCD20(IHC×200);C:ThepositiveexpressionofKi-67(IHC×200);D:ThepositiveexpressionofCD56(IHC×200)图2鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者病理常规及免疫组织化学Figure2PathologicalandimmunohistochemicalstainingofthepatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy图3鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者鼻咽18F-FDGPET-CT影像学表现Figure3Nasopharyngeal18F-FDGPET-CTimagingofpatientwithnasalNK/TcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapyA,B:Differentviewsofthesamecells图4鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者外周血细胞形态（瑞士-吉姆萨染色×1000）Figure4PeripheralbloodcellmorphologyofpatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy(Switzerland-Giemsastaining×1000)A,B:Differentviewsofthesamecells图5鼻腔NK/T细胞淋巴瘤治疗后并发传染性单核细胞增多症患者骨髓细胞形态（瑞士吉姆萨染色×1000）Figure5BonemarrowcellsmorphologyofpatientwithnasalNK/Tcelllymphomacomplicatinginfectiousmononucleosisafterchemotherapy(Switzerland-Giemsastaining×1000)
【参考文献】：
期刊论文
[1]原发心脏淋巴瘤的临床病理特征及治疗分析[J]. 董菲,李敏,景红梅,王晶,克晓燕. 肿瘤防治研究. 2015(07)
[2]NK/T细胞淋巴瘤患者中血浆EB病毒含量检测及其临床意义[J]. 刘阳,林全德,刘玉章,赵俊梅,王超,喻凤宽,张龑莉,李玉富,房佰俊. 中国实用医药. 2014(02)
[3]儿童传染性单核细胞增多症多个临床检测指标的诊断价值[J]. 伏洁,崔红,周士新. 武警医学. 2013(09)
[4]成人传染性单核细胞增多症患者56例临床及实验室特征分析[J]. 谢杨新,秦恩强,李文刚,许文,徐哲,张昕,周志平,陈威巍,聂为民,赵敏. 疑难病杂志. 2013(07)
[5]儿童EB病毒感染相关性噬血细胞综合征临床特点分析[J]. 郭霞,李强,周晨燕,赵亚宁. 中国实验血液学杂志. 2013(02)
[6]儿童传染性单核细胞增多症96例诊治体会[J]. 雷玲侠,刘小乖,李亚绒. 陕西医学杂志. 2012(09)
[7]淋巴瘤相关性噬血细胞综合征一例[J]. 谭松. 中国全科医学. 2010(14)
本文编号：3060874
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