胎盘中转运体的功能性表达与调控

发布时间：2017-12-28 06:02

本文关键词：胎盘中转运体的功能性表达与调控　出处：《药学学报》2016年06期 　论文类型：期刊论文

【摘要】：胎盘是妊娠期间联系胎儿与母体的重要器官,胎盘屏障在物质交换中起重要作用。胎盘合胞体滋养层细胞中表达有多种转运体,包括ATP结合盒转运体(ABC)和溶质运载转运体(SLC)两大类,其中有一些起到摄取物质的作用,如有机阳离子转运体(OCTs)和有机阴离子转运体(OATs)等,还有些介导多种药物、毒物及内源性物质的外排,如P-糖蛋白(P-gp)、乳腺癌耐药蛋白(BCRP)和多药耐药相关蛋白(MRPs)等。上述转运体在胎盘中的表达并非一成不变,它们可能会随着胎儿的发育而变化,或受某些生理、病理因素及药物的调控。因此,了解胎盘中转运体的种类和功能、调控及机制,将在产科学中发挥积极作用,对妊娠期安全用药具有重要的临床意义,对研究开发妊娠期安全使用的药物也有重要价值。
[Abstract]:Placenta is an important organ associated with the fetus and mother during pregnancy, and the placental barrier plays an important role in material exchange. Placental syncytiotrophoblast cells express a variety of transporters, including ATP binding cassette transporter (ABC) and solute carrier transporters (SLC) two categories, some of which have played a role as the uptake of materials, organic cation transporter (OCTs) and organic anion transporter (OATs), mediated by a variety of drugs, some the poison and endogenous substances such as efflux, P- glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance associated protein (MRPs). The expression of these transporters in placenta is not static. They may change with the development of the fetus, or be regulated by some physiological, pathological factors and drugs. Therefore, understanding the type and function, regulation and mechanism of placenta transporter will play an active role in the science of production. It has important clinical significance for safe medication during pregnancy, and is also valuable for research and development of drugs for safe use during pregnancy.
【作者单位】：浙江大学药学院;浙江大学医学院附属妇产科医院;
【基金】：国家自然科学基金资助项目(81302833)
【分类号】：R96
【正文快照】： 胎盘(placenta)是胚胎和母体子宫之间的一个圆形或椭圆形盘状器官,具有物质交换、代谢和分泌激素等功能,是妊娠期间联系胎儿与母体的重要器官。胎盘主要由羊膜、绒毛膜绒毛(chorionic villus)和蜕膜(decidua)构成,其主体部分是树枝状的绒毛。绒毛由外到内分别是滋养层、结缔组

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