酮洛芬固体分散体的制备及其体外溶出度研究

发布时间：2018-01-02 16:16

  本文关键词：酮洛芬固体分散体的制备及其体外溶出度研究　出处：《中国药业》2016年01期 　论文类型：期刊论文

  更多相关文章： 酮洛芬 固体分散体 体外溶出度 聚乙二醇

【摘要】：目的将酮洛芬制成固体分散体,考察其体外溶出特性。方法以聚乙二醇(PEG)为载体,用熔融法制备固体分散体,用正交试验筛选最优处方和制备工艺,X射线衍射法对其进行表征,并对固体分散体进行体外溶出度研究。结果固体分散体最优处方和工艺为,PEG 6000为载体,药物与载体比例为1∶5,制备温度为100℃,制备时间为30 min。制成的固体分散体在p H=7.6的介质中释放速率最快,45 min时溶出百分率为94.5%。结论酮洛芬固体分散体可显著提高酮洛芬的体外溶出速率。
[Abstract]:Objective To prepare the solid dispersion by using polyethylene glycol ( PEG ) as carrier and to prepare the solid dispersion by melt method . The optimal prescription and the preparation technology were selected by orthogonal test . The optimal prescription and the process were as follows : PEG 6000 as carrier , the ratio of drug to carrier was 1 鈭，

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