中药挥发油透皮促渗布洛芬的药动学及体内外相关性研究

发布时间：2018-01-10 07:23

本文关键词：中药挥发油透皮促渗布洛芬的药动学及体内外相关性研究　出处：《中国中药杂志》2016年23期 　论文类型：期刊论文

【摘要】：考察不同中药挥发油透皮促渗布洛芬的药动学及体内外相关性。以经典促渗剂氮酮为对照,分别制备含不同中药挥发油(川芎挥发油、当归挥发油和肉桂挥发油)的布洛芬凝胶剂,大鼠腹部给药,考察不同挥发油对布洛芬的透皮促渗效果。与不加促渗剂的对照组相比,川芎挥发油、当归挥发油、肉桂挥发油和氮酮促渗布洛芬的相对生物利用度分别为161.87%,171.05%,151.37%,148.66%。采用反卷积法分别对3种中药挥发油促渗下布洛芬凝胶体内外透皮的数据进行相关性分析,结果表明含川芎挥发油、当归挥发油和肉桂挥发油的3种布洛芬凝胶剂体内外透皮吸收结果相关性良好(r分别为0.999 7,0.995 2,0.999 4)。川芎挥发油、当归挥发油和肉桂挥发油能够显著提高布洛芬经皮给药的生物利用度,以凝胶剂为剂型的中药挥发油透皮促渗研究具有良好的体内外相关性。
[Abstract]:To investigate the pharmacokinetics and in vitro correlation of the transdermal permeation of ibuprofen from different Chinese medicine essential oils (Ligusticum chuanxiong) were prepared by taking azone as the control. Ibuprofen gel of Angelica sinensis and volatile oil of cinnamon) was administered to rats by abdominal administration to investigate the effect of different volatile oils on the transdermal permeability of ibuprofen. Compared with the control group without permeating agent, the volatile oil of Ligusticum chuanxiong was studied. The relative bioavailability of volatile oil of Angelica sinensis, cinnamon and azone was 161.87% and 151.37% respectively. By using deconvolution method, the data of ibuprofen gel in vivo and in vitro were analyzed by deconvolution method. The results showed that the volatile oil contained Ligusticum chuanxiong. There was a good correlation between in vitro and in vivo transdermal absorption of volatile oil of Angelica sinensis and Cinnamomum cassia volatile oil in vitro and in vivo, r = 0.999 7, 0.995 2 and 0.999 4, respectively. The volatile oil of Ligusticum chuanxiong was obtained. Angelica volatile oil and cinnamon volatile oil can significantly improve the bioavailability of ibuprofen through the skin.
【作者单位】：南京中医药大学江苏省中药资源产业化过程协同创新中心;南京中医药大学药学院药物制剂研究室;
【基金】：江苏省高校自然科学研究项目(14KJB360001) 江苏省中药资源产业化过程协同创新中心项目(ZDXMHT-1-15) 江苏省“青蓝工程”和江苏省高校优势学科建设工程项目
【分类号】：R965
【正文快照】： 经皮给药制剂由于给药方便,已经逐渐发展成为继口服、注射之后的主要给药途径之一。由于皮肤的屏障作用,经皮给药制剂一般生物利用度受到限制,应用透皮吸收促进剂(透皮促渗剂,penetrationenhancers)是解决这一问题的最常用方法。中药挥发油是一大类性质优良的透皮吸收促进剂[1

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